表型组精密测量平台简介之人体能量代谢舱平台

科学研究表明，能量代谢失衡与糖尿病、肥胖、心血管疾病、癌症等一系列重大慢性非传染性疾病以及老龄化密切相关。加强对机体能量代谢调控机制的研究，是应对慢病挑战的关键所在。

复旦大学人类表型组研究院代谢舱是国内第一、也是唯一的符合药物临床实验管理规范的临床级人体能量代谢平台，具备超强稳定性和高精度，配备有两间6㎡的密闭舱室。系统配置可用于完成临床级间接能量代谢监测，集成环境控制、受试人员膳食、饮水、体重、活动度监测（通过无线可穿戴设备）。能够高精度、长时间地测量体力活动能量消耗值（24小时以上），对受试者日常体力活动的影响较小；可对人体在静息、日常生活、运动等各种状态下进行精确的能量代谢监测；

测试者可以在密闭舱内自由活动几小时至数天（自由活动包括饮食、睡眠、运动等），通过高精度地采集、分析、观察、记录人体呼出CO2和吸入O2含量的变化来计算人体能量代谢的各项指标，同时还可以通过模拟高海拔低氧等环境，来测量人体在特定环境下的能量代谢情况。是目前世界上能量消耗测量的“金标准”。

Scientific studies have demonstrated that imbalances in energy metabolism are closely linked to major chronic non-communicable diseases such as diabetes, obesity, cardiovascular diseases, and cancer, as well as to aging. Understanding the regulatory mechanisms of human energy metabolism is therefore critical to addressing the challenges of chronic diseases.

The Metabolic Chamber at the Human Phenome Institute of Fudan University is the first and only clinical-grade human energy metabolism platform in China that complies with Good Clinical Practice (GCP) standards for drug trials. With exceptional stability and high precision, the facility is equipped with two airtight chambers of approximately 6 m² each. It enables clinical-grade indirect calorimetry and integrates environmental control, dietary and water intake management, body weight measurement, and activity monitoring through wireless wearable devices. This allows for precise, long-term (≥24 hours) measurement of energy expenditure with minimal disruption to participants’ daily activities, covering resting, daily living, and exercise states.

Participants can remain in the chamber for several hours to multiple days, during which they can eat, sleep, and exercise freely. Continuous monitoring of exhaled CO₂ and inhaled O₂ enables the calculation of comprehensive energy metabolism parameters. The chamber can also simulate environments such as high altitude and hypoxia, thereby allowing assessment of metabolic responses under specific conditions. This system is widely regarded as the global “gold standard” for measuring human energy expenditure.

人体能量代谢舱舱体Human energy metabolism chamber

复旦大学代谢舱配备两间舱体，每间体积：6㎡，舱内具有高精度环境控制(温度、湿度)特点，可以测定的人体代谢数据具有高精度数据和可重复性。并且配备模拟0-7500米海拔高度的氧气浓度大的低氧系统。舱体独立食物传递窗口，独立粪便传递窗口，独立采血窗口；内部定制床、桌椅。

Fudan University’s metabolic chamber is equipped with two chamber units, each with an area of 6 m². The chambers feature high-precision environmental control (temperature and humidity), ensuring that human metabolic data obtained are highly accurate and reproducible. In addition, the system includes a hypoxia module capable of simulating oxygen concentrations equivalent to altitudes ranging from 0 to 7,500 meters. Each chamber is designed with independent windows for food delivery, fecal sample collection, and blood sampling, and is furnished with custom-made beds, tables, and chairs.

低氧环境模拟Simulation of hypoxic environment

通过模拟高海拔环境（0-7500米）来诱导低氧环境，实现对低氧环境下的人体能量代谢研究;

低氧舱体可单独设置，自动运行;

Simulated high altitude environment (0-7500 m) was used to induce hypoxia environment to realize the study of human energy metabolism under hypoxia environment.

The hypoxic chamber can be set up independently and run automatically.

2

通过人体能量代谢舱设备直接提供的测量内容

Measurement content directly provided by the human energy metabolism chamber equipment

3可以与人体能量代谢舱结合研究的复杂派生变量

Complex derived variables that can be studied in combination with the human energy metabolism chamber

4可以用人体能量代谢舱测量的生理状态

The primary functions of the human metabolism chamber are described.

5人体能量代谢舱可为以下方面的研究提供平台

The human energy metabolism chamber can provide a platform for research on

1.人体基础代谢研究：如肥胖、糖尿病；

2.生活方式、营养学与能量消耗的关系；

3.体育锻炼与能量消耗的关系；

4.温度、光照与能量消耗的关系；

5.处方药、中药和人体代谢率的关系；

6.代谢组学与肠道菌群等...

1. Human basic metabolic research: such as obesity and diabetes;

2. The relationship between lifestyle, nutrition and energy expenditure;

3. The relationship between physical activity and energy expenditure;

4. The relationship between temperature, light and energy consumption;

5. The relationship between prescription drugs, traditional Chinese medicine and human metabolic rate;

6. Metabolomics and gut microbiota...

1.中国人群基础代谢率测试；

2.特殊环境和海拔基础代谢率测试；

3.天然产物对人群基础代谢笼测试；

4.减重药物对人群基础代谢率测试。

1. Basal metabolic rate test in Chinese population;

2. Basal metabolic rate test in special environment and altitude;

3. Basal metabolic cage test of natural products on population;

4.Basal metabolic rate test of weight-loss drugs in the population.

刘铁民 

Tiemin Liu

教授，人体代谢舱研究平台负责人

Professor，Head of the Room Calorimetry research platform

刘铁民教授，复旦大学生命科学学院生理学与神经生物学系主任，人类表型组研究院高级专家，复杂性状的遗传调控全国重点实验室课题组长，复旦大学附属中山医院特聘教授，内蒙古大学生物医学研究院副院长。国家重点研发计划“发育编程及其代谢调节”重点专项关于神经调控代谢领域的项目首席科学家。主要研究中枢神经及外周脂肪、肌肉、肝脏等组织在能量平衡和糖脂代谢调节中的重要作用。结合生理学和神经学来研究肥胖症、糖尿病及代谢综合征的病理机制。着眼于将基础科研中的新发现转化为新颖的药理和临床干预疾病等应用型研究。已在Cell，Cell Metabolism，Neuron，Nature Neuroscience等国际顶级刊物发表论文100多篇。

Professor Liu Tiemin, Head of Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Senior expert of the Institute of Human Phenome, project leader of the State Key Laboratory of Genetics and Development of Complex Phenotypes, Distinguished Professor of Zhongshan Hospital Affiliated to Fudan University, Vice President of Biomedical Research Institute of Inner Mongolia University. He is the chief scientist of the National Key Research and Development Program "Developmental Programming and Metabolic Regulation" Key project in the field of neuroregulation and metabolism. It mainly studies the important role of central nervous system and peripheral fat, muscle, liver and other tissues in the regulation of energy balance and glucose and lipid metabolism. To study the pathological mechanism of obesity, diabetes and metabolic syndrome by combining physiology and neurology. It focuses on the transformation of new discoveries in basic scientific research into novel pharmacological and clinical intervention of diseases. He has published more than 100 papers in top international journals such as Cell, Cell Metabolism, Neuron and Nature Neuroscience.