吴浩青年研究员,全职科研人员

 

博士、青年研究员


Email:hao_w@fudan.edu.cn

实验室主页:https://microbiome.fudan.edu.cn/main.htm



 工作经历

2002-2005,山东理工大学生命科学学院,获工学学士学位;

2007-2012,浙江大学沃森基因研究院,获理学博士学位;

2012-2014,中国科学院北京基因组研究所,助理研究员;

2015-2020,瑞典哥德堡大学Sahlgrenska医院,博士后;

2021-至今,复旦大学人类表型组研究院,青年研究员。

 研究方向

1)肠道内生态紊乱与肠道菌失衡;

2)肠道菌与糖尿病、心血管疾病等代谢性疾病之间的因果关系研究;

3)肠道菌对药物及饮食干预的影响;

4)多组学数据整合;

5)细菌基因组突变与进化研究。

 招生专业

微生物学或生物信息学

 代表论文

1. Hao Wu*, Valentina Tremaroli*, Caroline Schmidt, Annika Lundqvist, Lisa M Olsson, Manuela Krämer, Anders Gummesson, Rosie Perkins, Göran Bergström#, Fredrik Bäckhed#. The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study. 2020. Cell Metabolism 32 (3), 379-390. e3

2. Ara Koh, Antonio Molinaro, Marcus Ståhlman, Muhammad Tanweer Khan, Caroline Schmidt, Louise Mannerås-Holm, Hao Wu, Alba Carreras, Heeyoon Jeong, Louise E Olofsson, Per-Olof Bergh, Victor Gerdes, Annick Hartstra, Maurits de Brauw, Rosie Perkins, Max Nieuwdorp, Göran Bergström, Fredrik Bäckhed#. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. 2018. Cell 175 (4), 947-961. e17

3. Adil Mardinoglu*, Hao Wu*, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M Räsänen, Sunjae Lee, Rosellina M Mancina, Mattias Bergentall, Kirsi H Pietiläinen, Sanni Söderlund, Niina Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Brian D Piening, Marit Granér, Nina Lundbom, Kevin J Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed#, Marja-Riitta Taskinen, Jan Borén#. An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans. 2018. Cell metabolism 27 (3), 559-571. e5

4. Hao Wu*, Eduardo Esteve*, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real#, Fredrik Bäckhed#. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. 2017. Nature medicine 23 (7), 850

5. Hao Wu*, Valentina Tremaroli*, Fredrik Bäckhed#. Linking microbiota to human diseases: a systems biology perspective. 2015. Trends in Endocrinology & Metabolism 26 (12), 758-770

6. Hao Wu, Yongjun Fang, Jun Yu#, Zhang Zhang#. The quest for a unified view of bacterial land colonization. 2014. The ISME journal 8 (7), 1358-1369