Dr. Jun Chang acquired PhD degree on organic chemistry from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences in 2002, and joined SIMM as an assistant professor from 2002 to 2006. During 2004-2006, he worked as postdoctoral research associate in the University of Illinois at Chicago. From 2006 to 2009, he worked as a senior research director in the pharmaceutical company. From May 2009, Dr. Chang worked as assistant professor in Fudan University, and was promoted to associate professor in 2013. He was transferred to Human Phenome Institute as vice Dean in 2019.
Research Interests
Dr. Jun Chang focused on the research of pharmacophenomics, and the design, synthesis and druggability of small molecule tumor immunotherapy drugs. He has published more than 50 research papers, and applied for 21 domestic patents, 3 PCT patents, in which 13 patents have been authorized. He was the important inventor of the class 1.1 innovative anti-tumor drug Sinotecan (Chinese patent: ZL03142241.1), which was approved for clinical research (2011L00694，2011L00695) in 2011.
Awards
He won the second prize of Shanghai Pharmaceutical Science and Technology Award (ranked 3rd) in 2012.
Selected Publications
1. Mei-Lin Tang, Jin-Feng Ning, Yu-Hui Li, Heyanhao Zhang, Mi Liu, Yejun Dong, Jun Chang*. Sulfoxide-Mediated Approach to Flavones Through One-pot Knoevenagel Condensation / Oxa-Michael Addition / Sulfoxide Elimination Process of ß-(o-hydroxyaryl)-ketosulfone With Arylaldehydes. Tetrahedron Letters 2023, 116, 154336.
2. Mei-Lin Tang, Zi-Hao Wen, Jing-Huan Wang, Mei-Ling Wang, Heyanhao Zhang, Xin-Hua Liu, Lin Jin*, Jun Chang*. Discovery of Pyridone-substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke. ACS Medicinal Chemistry Letters. 2022, 13, 436-442.
3. Heyanhao Zhang, Lin Jin, Ju-Bao Zhang, Tong Niu, Tao Guo*, Jun Chang*. Chemical constituents from the bulbs of Lilium davidii var. unicolor and anti-insomnia effect. Fitoterapia 2022, 161, 105252.
4. Yang Lin, Heyanhao Zhang, Tong Niu, Mei-Lin Tang*, Jun Chang*. Discovery of novel indoleamine 2,3-dioxygenase 1 (IDO1) and histone deacetylase 1 (HDAC1) dual inhibitors derived from the natural product saprorthoquinone. Molecules 2020, 25, 4494.
5. Ya-Lin Liu, Liang-Liang Gao, Tong-Tong Song, Tao Guo*, Jun Chang*. Two new sesquiterpenoid glycosides from the stems of Zanthoxylum armatum DC. Nat. Prod. Res. 2020, 34(21), 3036-3041.
