Work Experience
Dr. Bin-Zhi Qian is a Distinguished Professor in the Human Phenome Institute at Fudan University, China. He also holds an honorary fellow position with joint appointment in the Centre for Reproductive Health at the University of Edinburgh (UoE), UK. Dr. Qian received his bachelor’s degree in Biochemistry from Fudan University in Shanghai, China. He received a Ph.D. degree in Biomedical Sciences from Albert Einstein College of Medicine in New York, USA, under the mentorship of Professor Jeffrey Pollard. Following postdoctoral training with Dr. Charles Sawyers at Memorial Sloan Kettering Cancer Center in New York, he started his independent research group at UoE in 2013.
Before joining Fudan, Prof. Qian held dual appointments as a tenured Reader (full professor) at Edinburgh Cancer Center and Center for Reproductive Health of the University of Edinburgh, UK. Prof. Qian has a long-standing focus on tumor metastasis and immune microenvironment, elucidated the critical role of macrophages in cancer metastasis and is pioneering the field of metastasis-associated macrophages. He has published nearly 40 high-impact academic papers in renowned international journals such as Nature, Cell, and Nature Review Immunology, with a total citation over 14,300 and a cumulative impact factor of 334. Among these publications, 8 were rated as highly cited articles by Web of Science. He has successfully transferred one international invention and led several major international research projects with funding over 28 million Chinese Yuan.
Prof. Qian has now established a state-of-the-art integrated spatial-omics research platform in Fudan University. This platform is dedicated to making significant breakthroughs on spatial-omics technology, data analysis algorithms, and scientific/clinical applications through a multi-disciplinary approach with the goal of advancing the Human Phenome Project, promoting precision medicine, and fostering the advancement of all related research fields.
Research Interests
Space omics；tumour immunology (innate immunity)；tumour microenvironment；bioinformatics
Enrollment major
Biology
Awards
2015 Head of College Award (early achievement award), University of Edinburgh
2014 Cancer Research UK Career Development Fellowship Award, CRUK
2013 Movember-Prostate Cancer Foundation Challenge (Young Investigator) Award
2013 The Dennis Shields Memorial Fund Research Award (Best Postdoctoral Research Award), Albert Einstein College of Medicine, New York, USA
2012 Susan G. Komen for the Cure Postdoctoral Fellowship Award
2012 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award for the AACR 103rd Annual Meeting 2012
2011 AACR-Susan G. Komen Scholar-in-Training Award for the AACR 102nd Annual Meeting 2011
Selected Publications
1. Yang Y, Chen Y, Pei P, Fan Y, Wang S, Zhang H, Zhao D, Qian BZ, Zhang F. Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging. Nat Nanotechnol. 2023 Jun 22. doi: 10.1038/s41565-023-01422-2.
3. Li XF, Selli C, Zhou H, Cao J, Wu S, Ma RY, Lu Y, Zhang CB, Xun B, Lam AD, Pang XC, Fernando A, Zhang Z, Unciti-Broceta A, Carragher NO, Ramachandran P, Henderson NC, Sun LL, Hu HY, Li GB, Sawyers C, Qian BZ. Macrophages promote anti-androgen resistance of prostate cancer bone disease. J Exp Med. 2023 Apr 3;220(4):e20221007. doi: 10.1084/jem.20221007.
4. Ma RY; Black A; Qian BZ. Macrophage diversity in cancer revisited in the era of single-cell omics. Trends Immunol. 2022 Jul;43(7):546-563. DOI: 10.1016/j.it.2022.04.008
5. Zhou Y, Yang D, Yang QC, Lv XB, Huang WT, Zhou Z, Wang YL, Ding X, Tang LN, Zhang JJ, Yin JY, Huang YJ, Yu WX, Wang YG, Chen- Zhou L, Su Y, Guo-Wei Qian, He AN, Sun YJ, Shen Z, Qian BZ, Chen PZ, Yao Y, Hu HY. Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma. Nat Com. 2020 Dec 10;11(1):6322.
6. Ma RY, Zhang H, Li XF, Zhang CB, Selli C, Tagliavini G, Prost S, Sims AH, Hu HY, Ying T, Wang Z, Ye Z, Pollard JW, Qian BZ. Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth. J Exp Med. 2020, 217 (11): e20191820
7. Pang, X, Gong, K, Zhang, X, Wu, S, Cui, Y, and Qian BZ (2019). Osteopontin as a multifaceted driver of bone metastasis and drug resistance. Pharmacol. Res. 144, 235-244.
8. Graham N, Qian BZ. Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis. Int. J. Mol. Sci. 2018, 19(4), 1121; doi:10.3390/ijms19041121
9. Gómez-Cuadrado L, Tracey N, Ma R, Qian BZ, Brunton VG Mouse models of metastasis: progress and prospects. Disease Models and Mechanisms. 2017 Sep 1;10(9):1061-1074. doi: 10.1242/dmm.030403.
10. Qian BZ. Inflammation fires up cancer metastasis. Seminars in Cancer Biology. 2017 Aug 31. pii: S1044-579X(17)30210-9. doi: 10.1016/j.semcancer.2017.08.006
11. Cao J, Liu J, Xu R, Zhu X, Zhao X, Qian BZ. Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: A systematic review and meta-analysis. Oncotarget. 2017 Jun 27; : 1–9. doi: 10.18632/oncotarget.18743.
12. Qin W, Zheng Y, Qian BZ#, Zhao M# Prostate cancer stem cells and nanotechnology: a focus on Wnt signaling. Front. Pharmacol. 2017 Mar 28; 8: 153 (# co-corresponding author)
13. Hughes R*, Qian BZ* Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW and Lewis CE. Perivascular M2 macrophages Stimulate Tumor Relapse After Chemotherapy. Cancer Research. 2015 Sep 1;75(17):3479-91 (co-first author)
14. Qian BZ#, Zhang H, Li J, He AT, Yeo EJ, Soong DYH, Carragher N, Munro A, Chang A, Bresnick AR, Lang RA and Pollard JW# FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J Exp Med 2015 Aug 24; 212(9):1433-48. (# co-corresponding author)
15. Harney AS, Arwert EN, Entenberg D, Wang Y, Qian BZ, Pollard JW, Jones JG and Condeelis JS. Real-time imaging reveals local, transient vascular permeability and tumor cell intravasation by Tie2Hi macrophage-derived VEGFA. Cancer Discov 2015 Sep;5(9):932-43.
16. Kitamura T, Qian BZ, Soogn D, Cassetta L, Noy R, Sugano G, Kato Y, Li J and Pollard JW CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J Exp Med 2015 Jun 29;212(7):1043-59.
17. Kitamura T, Qian BZ and Pollard JW Immune cell promotion of metastasis. Nature Review Immunology 2015 Feb. 2: 73-86.
18. Qian BZ, Li J, Zhang H, Kitamura T, Campion LR, Kaiser EA, Zhang J, Snyder LA and Pollard JW. CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis. Nature. 475, 222-25 July 14, 2011.
19. Qian BZ, Pollard JW. Macrophage Diversity Enhances Tumor Progression and Metastasis. Cell. 141, 39-51 April 2, 2010
20. Qian BZ, Deng Y, Im JH, Muschel RJ, Zou Y, et al. 2009. A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth. PLoS ONE. 4(8): e6562.
