Jiucun WangProfessor

Professor of Genetics and the Director of the Department of Anthropology and Human Genetics, School of Life Sciences, 

Fudan University, Shanghai the Deputy Director of Institute of Rheumatology, Immunology and Allergy, Fudan Universit Doctoral Supervisor



  Work Experience

Dr. Wang graduated from Fudan University with B.S. and M.S. in biology, and obtained Ph.D. in applied biochemistry from Fukui University, Japan. She was a postdoctoral fellow and research scholar at the Division of Rheumatology and Clinical Immunogenetics of the University of Texas Health Science Center at Houston from 2007 to 2008.  She was lecturer at Fudan University from 1991-1994, and Assistant/Associate Professor/Professor at the School of Life Sciences, Fudan University since 2000.

She serves as the Associate Board Director and Executive Committee Member of the International Network of Scleroderma Clinical Care and Research (InSCAR) and the Secretary General of Fudan-Taizhou Institute of Health Sciences. She also serves as the Secretary General of Shanghai Society of Genetics, Co-Director of the Joint Laboratory of Skin Phenome. She serves as an Editorial Board Member for Laboratory Investigation, Journal of Scleroderma and Related Disorders, and Gout and Hyperuricemia. She published more than 100 papers in peer-reviewed journals in recent 5 years.

 Research Interests

She works on the genetics and molecular mechanism of scleroderma, as well as the molecular epidemiology of ankylosing spondylitis. She led one program of the International S & T Cooperation, and several NSFC Projects. As a Site PI, she led the Chinese effort in one NIH-U01 project entitled “Studies of HLA Region Genomics in Systemic Sclerosis and Ankylosing Spondylitis”.

 Selected Publications

1、Shi X, Chen Y, Liu Q, Mei X, Liu J, Tang Y, Luo R, Sun D, Ma Y, Wu W, Tu W, Zhao Y, Xu W, Ke Y, Jiang S, Huang Y, Zhang R, Wang L, Chen Y, Xia J, Pu W, Zhu H, Zuo X, Li Y, Xu J, Gao F, Wei D, Chen J, Yin W, Wang Q, Dai H, Yang L, Guo G, Cui J, Song N, Zou H, Zhao S, Distler JHW, Jin L, Wang J*. LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis. Clin Transl Med. 2022 Jan;12(1):e711. doi: 10.1002/ctm2.711. PMID: 35083881.

2、Pu W#, Zhang R#, Ma Y, Liu Q, Jiang S, Liu J, Zhao Y, Tu W, Guo G, Zuo X, Wang Q, Chen Y, Wu W, Zhou X, Distler JHW, Reveille JD, Zou H, Jin L, Mayes MD, Wang J*. Genetic Associations of Non-Major Histocompatibility Complex Susceptibility Loci with Systemic Sclerosis in a Han Chinese Population. J Invest Dermatol. 2021 Dec 15:S0022-202X(21)02614-2. doi: 10.1016/j.jid.2021.11.033. Online ahead of print. PMID: 34919939

3、Pu W#, Wu W#, Liu Q#, Ma Y#, Tu W#, Zuo X#, Guo G#, Jiang S, Zhao Y, Zuo X, Wang Q, Yang L, Xiao R, Chu H, Wang L, Sun L, Cui J, Yu L, Li H, Li Y, Shi Y, Zhang J, Zhang H, Liang M, Chen D, Ding Y, Chen X, Chen Y, Zhang R, Zhao H, Li Y, Qi Q, Bai P, Zhao L, Reveille JD, Mayes MD, Jin L, Lee EB, Zhang X, Xu J*, Zhang Z*, Zhou X*, Zou H*, Wang J*. Exome-wide association analysis suggests LRP2BP as a susceptibility gene for endothelial injury in systemic sclerosis in Han Chinese population. J Invest Dermatol. 2021 May;141(5):1254-1263.e6. doi: 10.1016/j.jid.2020.07.039. Epub 2020 Oct 15. PMID: 33069728

4、Liu J#, Tang Y#, Huang Y#, Gao J, Jiang S, Liu Q, Ma Y, Qian X, Qian F, Reveille JD, He D, Zou H, Jin L, Zhu Q*, Pu W*, Wang J*. Single-cell RNA Sequencing Deciphers Innate Immunity in Pathogenesis and Treatment Response of Ankylosing Spondylitis. Clin Transl Med. 2021 Mar;11(3):e369. doi: 10.1002/ctm2.369. PMID: 33784007

5、Li Z#, Xia J#, Jiang L#, Tan Y#, An Y, Zhu X, Ruan J, Chen Z, Zhen H, Ma Y, Jie Z, Xiao L, Yang H, Wang J, Kristiansen K, Xu X, Jin L, Nie C*, Krutmann J*, Liu X*, Wang J*. Characterization of the human skin resistome and identification of two microbiota cutotypes. Microbiome. 2021 Feb 17;9(1):47.  

Full paper: ttps://link.springer.com/content/pdf/10.1186/s40168-020-00995-7.pdf

Video Byte: https://www.researchsquare.com/article/rs-276355/v1.

6、Sun D#, Niu Z#, Zheng H#, Wu F, Jiang L, Han TQ, Wei Y, Wang J*, Jin L*. A mitochondrial DNA variant elevates the risk of gallstone disease by altering mitochondrial function. Cell Mol Gastroenterol Hepatol. 2020 Dec 4:S2352-345X(20)30199-5.

7、Liu J#, Pu W#, Li Y, Ma Y, Zhu Q, Wan W, Yang C, Wang X, Chen X, Zhou X, Reveille JD, Jin L, Zou H*, Wang J*. Genetic association of non-MHC region with ankylosing spondylitis in a Chinese population. Ann Rheum Dis. 2019 Jun;78(6):852-853.

8、Guo S#, Jiang S#, Epperla N, Ma Y, Maadooliat M, Ye Z, Olson B, Wang M, Kitchner T, Joyce J, An P, Wang F, Strenn R, Mazza JJ, Meece JK, Wu W, Jin L, Smith JA, Wang J* and Schrodi SJ*. A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron metabolism gene. Blood. 2019Apr 25;133(17):1888-1898.

9、Ding W#, Pu W#, Wang L#, Jiang S, Zhou X, Tu W, Yu L, Zhang J, Guo S, Liu Q, Ma Y, Chen S, Wu W, Reveille J, Zou H, Jin L, Wang J*. Genome-wide DNA methylation analysis in systemic sclerosis reveals hypomethylation of interferon-associated genes in CD4+ and CD8+ T cells. J Invest Dermatol. 2018 May;138(5):1069-1077.

10、Dong Z#, Li Y#, Zhou J, Jiang S, Wang Y, Chen Y, Zhao D, Yang C, Qian Q, Ma Y, He H, Ji H, Yang Y, Wang X, Xu X, Pang Y, Zou H, Jin L, Zhang F*, Wang J*. Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout. Protein Cell. 2017 Jun;8(6):467-470.