Xiang Jun ChenProfessor

Professor of Neurology, Chief physician, Doctoral supervisor

Vice Chair, Institute of Neurology, Fudan University、Vice Chair, Institute of Rheumatology, Immunology & Allergy, Fudan University、PI, Human Phenome Institute, Fudan University、Deputy director, Scientific Research Department, Huashan Hospital, Fudan University、Deputy director, Huashan Hospital Core Laboratory、Shanghai "Pu-Jiang talent"、Deputy Secretary General, 12th Council of Shanghai Immunology Society; & Chairman of the Neuroimmunology Committee, Shanghai Immunology Society、Council member, Chinese Society for Immunology、Committee member, International Peripheral Nerve Society、Committee member, Standardization Administration of China (SAC / TC559)

Email:xiangjchen@fudan.edu.cn

 Work Experience

B.S. Med., Zhejiang University (1993)

M.S. of Neurology, Zhejiang University (1996)

M.D. of Neurology, Fudan University (2001)

Post-doc of Neurosurgery, University of Michigan, USA (2001-2002)

Post-doc of Neurology, University of Chicago, USA (2002-2007)

Department of Neurology, Huashan Hospital, Fudan University (2007- )

Institute of Neurology, Fudan University (2007- )

Human Phenome Institute, Fudan University (2020- )

  Research Interests

(1) Animal model and pathogenesis of motor neuron disease / amyotrophic lateral sclerosis (“Lou Gehrig’s disease”); especially focus on the retrograde axonal transport and the pyroptosis-based mechanism of motor neuron degeneration;

(2) Cohort-based phenotypic characterization and pathogenesis of neuroimmune diseases, especially focus on the common immune pathogenesis of encephalitis, neuromyelitis optica spectrum disorders, multiple sclerosis, Guillain-Barre syndrome, myasthenia gravis, etc;

(3) High-throughput and accurate detection technology of neuroimmune diseases; and the translational study of neuro-immunological biomarkers based on molecular biology, immunofluorescence labeling, bioinformatics and other edge-cutting technologies.

 Selected Publications

1、Chen XJ*, Li HF. A narrative review of identifying the culprit antibody in neuroimmune diseases: concept and clinical significance. Ann Transl Med 2023. doi:10.21037/atm-21-1627

2、Bo Deng, Jingguo Wang, Hai Yu, Lei Jin, Yue Qiu, Xiaoni Liu, Pengyu Wang, Xiang Zhang, Xiangjun Chen*. Area Postrema Syndrome in Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy A Case Series and Literature Review. Neurology: Neuroimmunology & Neuroinflammation. 2022;9:e200029. doi:10.1212/NXI.0000000000200029

3、Siqi Dong, Dongqing Zhu, Wenbo Yang, Jiatong Li, Xiangjun Chen*. Prominent lower motor neuron involvement in patients with intermediate‑length CAG repeats in ATXN3 gene. Neurological Sciences. Received: 3 June 2022/Accepted: 5 August 2022. https://doi.org/10.1007/s10072-022-06325-z

4、Jia-Tong Li, Si-Qi Dong, Dong-Qing Zhu, Wen-Bo Yang, Ting Qian, Xiao-Ni Liu and Xiang-Jun Chen*. Expanding the Phenotypic and Genetic Spectrum of Neuromuscular Diseases Caused by DYNC1H1 Mutations. Frontiers in Neurology. July 2022, Volume 13, Article 943324 https://doi.org/10.3389/fneur.2022.943324

5、Xiang Zhang, Xiaoni Liu, Hai Yu, Bo Deng, Yue Zhang, Xiangjun Chen*, Longitudinal evaluation of clinical characteristics of Chinese neuromyelitis optica spectrum disorder patients with different AQP4-IgG serostatus. Multiple Sclerosis and Related Disorders. 62(2022)103786.

6、Yi Zhang#, Haocheng Zhang#, Bo Deng#, Ke Lin#, Lei Jin#, Xiaoni Liu, Yanlin Zhang, Xiaohua Chen,Yanliang Zhang, Shengjia Lu, Heqing Huang, Qiujing Wang, Tingting Feng, Weifeng Zhao, Qun Xue, Renfang Chen, Jingbo Zhang, Xiaoyan Qian, Lanlan Chen, Jingwen Ai*, Xiangjun Chen* and Wenhong Zhang*.Optimal encephalitis/meningitis roadmap via precise diagnosis and treatment (IMPROVE):a study protocol for a randomized controlled trial. BMC Infectious Diseases (2022) 22:40. https://doi.org/10.1186/s12879-021-06943-6

7、Gao WQ#, Li YY#, Liu XH, Wang S, Mei PC, Chen ZJ, Liu KW, Li SH, Xu XW, Gan JH, Wu JX, Ji CN, Ding C, Liu X, Lai YP, He HS, Lieberman J, Wu H, Chen XJ*, and Li JX*. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death & Differentiation,2021; https://doi.org/10.1038/s41418-021-00867-z.

8、Jingjie Ge#, Bo Deng#, Yihui Guan, Weiqi Bao, Ping Wu, Xiangjun Chen* and Chuantao Zuo*. Distinct cerebral 18F-FDG PET metabolic patterns in anti-N-methyl-D-aspartate receptor encephalitis patients with different trigger factors. Therapeutic Advances in Neurological Disorders. 2021, Vol. 14: 1–12. DOI: 10.1177/1756286421995635

9、Hai-Feng Li*, Hong-Jun Hao, Xiang-Jun Chen. Provisional case definitions for COVID-19-associated neurological disease. The Lancet Neurology. 2020, 19(11): 890-891.doi: 10.1016/S1474-4422(20)30373-2