Dr. Shuhua Xu is professor of human population genetics and Principal Investigator of Population Omics Group at Fudan University. He joined Chinese Academy of Sciences (CAS) and Max-Plank Partner Institute for Computational Biology (PICB) in 2006 after he received his PhD at Fudan University. He was appointed the position of Principal Investigator in 2009 and led the Population Genomics Group (PGG). He was appointed the position of Max-Planck Independent Research Group Leader in 2011, and supported by both Max-Planck and CAS from 2012 to 2018. He is currently holding a Distinguished Professorship in Chinese Academy of Sciences and a Distinguished Adjunct Professorship at ShanghaiTech University, China. Dr. Xu serves as Editorial Board member of several international peer-reviewed journals such as JGG, Hereditas, Human Genomics, Molecular Genetics and Genomics (co-Editor-in-Chief), Frontier in Genetics, Scientific Reports, BMC Genetics (Section Editor), BMC Genomic Data (Senior Editor).
Population Omics/Human Genetics/Molecular Evolution/Bioinformatics/Computational Biology
Dr. Xu uses computational approaches and develops new methods to dissect genetic architecture of human populations, quantitatively characterize their admixture features, and reveal their migration history and adaptive divergence. Dr. Xu has authored many scientific papers published in Science, Cell, PNAS, Nature Genetics, Nature Communications, Genome Biology, American Journal of Human Genetics, Nucleic Acids Research, Genome Research, Molecular Biology and Evolution, the PLoS and the BMC series.
Excellent Editorial Board Member in 2020, Journal of Genetics and Genomics (China) (2020)
he Royal Society Newton Advanced Fellowships (UK) (2019 – 2022)
2019 "Top Ten Scientific and Technological Progress" of Genetic and Development Collaborative Innovation Center (2020)
Top Ten Progresses of Chinese Bioinformatics in 2019 (2020)
Top Ten Databases of Chinese Bioinformatics in 2019 (2020)
"Innovative Talent Promotion Plan" Young and Middle-aged Leaders in Scientific and Technological Innovation, Ministry of Science and Technology (2018)
1st Class Prize of Natural Science Award, Ministry of Education (2018)
Chinese Academy of Sciences President's Award for Excellence (2018)
Shanghai Academic Research Leader (2016)
Distinguished Principal Investigator of Chinese Academy of Sciences (CAS) (2015)
Outstanding Member of the 1st Chinese Academy of Sciences Youth Innovation Promotion Association (CAS) (2015)
Distinguished Young Scholars of National Science Fund (2015)
2nd Class Prize of Natural Science Award, State Council (2015)
Youth Committee Member of the 9th Council Meeting of Chinese Society of Genetics (2013)
Outstanding Member of Chinese Academy of Sciences (CAS) Youth Innovation Promotion Association (CAS) (2013)
The National Top-notch Young Innovative Talent supported by The "Ten-Thousand-Talents" Project (“Wanren Jihua”) (2013)
Thesis Advisor for 2012 SIBS-Eli Lilly Outstanding Graduate Thesis Award Winner (US) (2012)
Distinguish Young Scientist, Chinese Academy of Sciences (2012)
1st Class Prize of Natural Science Award, Ministry of Education (2012)
Shanghai Rising-Star, bestowed by Science and Technology Commission of Shanghai Municipality (2011)
Top 100 National Excellent Doctoral Dissertation Award in China (Ministry of Education of China & Academic Degrees Committee of the State Council) (2011)
Award of the Excellent Doctoral Dissertation (Fudan University) (2010)
Award of the Excellent Doctoral Dissertation of Shanghai (Shanghai Municipal Education Commissions) (2009)
Sanofi Aventis (SA)-SIBS 2009 Young Faculty Award (France) (2009)
Life Science Award, Shanghai, MEIJI Dairies Corp (Japan) (2009)
Chia-Si Lu Scholarship of Chinese Academy of Sciences (CAS) (2009)
Xixian Ma#, Wenjun Yang#, Yang Gao, Yuwen Pan, Yan Lu, Hao Chen, Dongsheng Lu, Shuhua Xu*. Genetic origins and sex-biased admixture of the Huis. Molecular Biology and Evolution. 2021. Doi:10.1093/molbev/msab158.
Lan-Tao Gou, Yang Gao, Jun-Yan Kang, Xin Wang, Hao Chen, Min-Min Hua, Zheng Li, Dangsheng Li, Xiang-Dong Fu, Hui-Juan Shi*, Shuhua Xu* and Mo-Fang Liu*. Reply to Lack of evidence for a role of PIWIL1 variants in human male infertility. Cell. 2020. 184(8):1943-1944.
Hao Chen#, Yan Lu#, Dongsheng Lu & Shuhua Xu*. Y-LineageTracker: a high-throughput analysis framework for Y-chromosomal next-generation sequencing data. BMC Bioinformatics. 2021. 22:114.
Ziqing Pan and Shuhua Xu*. Population genomics of East Asian ethnic groups. Hereditas. 2020. 157:49.
Yang Gao#, Chao Zhang#, Liyun Yuan#, YunChao Ling, Xiaoji Wang, Chang Liu, Yuwen Pan, Xiaoxi Zhang, Xixian Ma, Yuchen Wang, Yan Lu, Kai Yuan, Wei Ye, Jiaqiang Qian, Huidan Chang, Ruifang Cao, Xiao Yang, Ling Ma, Yuanhu Ju, Long Dai, Yuanyuan Tang, The Han100K Initiative, Guoqing Zhang, Shuhua Xu*. PGG.Han: The Han Chinese Genome Database and Analysis Platform. Nucleic Acids Research. 2020, 48(D1):D971-D976.
Chao Zhang#, Yang Gao#, Zhilin Ning#, Yan Lu#, Xiaoxi Zhang, Jiaojiao Liu, Bo Xie, Zhe Xue, Xiaoji Wang, Kai Yuan, Xueling Ge, Yuwen Pan, Chang Liu, Lei Tian, Yuchen Wang, Dongsheng Lu, Boon-Peng Hoh, Shuhua Xu*. PGG.SNV: Understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations. Genome Biology. 2019, 20:215.
Lian Deng#, Chao Zhang#, Kai Yuan#, Yang Gao#, Yuwen Pan, Xueling Ge, Yaoxi He, Yuan Yuan, Yan Lu, Xiaoxi Zhang, Hao Chen, Haiyi Lou, Xiaoji Wang, Dongsheng Lu, Jiaojiao Liu, Lei Tian, Qidi Feng, Asifullah Khan, Yajun Yang, Zi-Bing Jin, Jian Yang, Fan Lu, Jia Qu, Longli Kang, Bing Su, Shuhua Xu*. Prioritizing natural selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders. National Science Review. 2019, 6(6):1201–1222.
Chao Zhang#, Yang Gao#, Jiaojiao Liu, Zhe Xue, Yan Lu, Lian Deng, Lei Tian, Qidi Feng, Shuhua Xu*. PGG.Population: a database for understanding the genomic diversity and genetic ancestry of human populations. Nucleic Acids Research. 2018, 46:D984–D993.
Chao Zhang#, Yan Lu#, Qidi Feng#, Xiaoji Wang#, Haiyi Lou, Jiaojiao Liu, Zhilin Ning, Kai Yuan, Yuchen Wang, Ying Zhou, Lian Deng, Lijun Liu, Yajun Yang, Shilin Li, Lifeng Ma, Zhiying Zhang, Li Jin, Bing Su, Longli Kang, Shuhua Xu*. Differentiated demographic histories and local adaptations between Sherpas and Tibetans. Genome Biology. 2017, 18:115.
Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*. Genetic history of Xinjiang’s Uyghurs suggests Bronze Age multiple-way contacts in Eurasia. Molecular Biology and Evolution. 2017, 34:2572-2582.
Dongsheng Lu, Haiyi Lou, Kai Yuan, Xiaoji Wang, Yuchen Wang, Chao Zhang, Yan Lu, Xiong Yang, Lian Deng, Ying Zhou, Qidi Feng, Ya Hu, Qiliang Ding, Yajun Yang, Shilin Li, Li Jin, Yaqun Guan, Bing Su, Longli Kang, and Shuhua Xu*. Ancestral Origins and Genetic History of Tibetan Highlanders. American Journal of Human Genetics. 2016, 99:580-594.
Haiyi Lou, Yan Lu, Dongsheng Lu, Ruiqing Fu, Xiaoji Wang, Qidi Feng, Sijie Wu, Yajun Yang, Shilin Li, Longli Kang, Yaqun Guan, Boon-Peng Hoh, Yeun-Jun Chung, Li Jin, Bing Su, Shuhua Xu*. A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence. American Journal of Human Genetics. 2015, 97(1):54-66.
Wenfei Jin, Sijia Wang, Haifeng Wang, Li Jin, Shuhua Xu*. Exploring Population Admixture Dynamics Using Empirical and Simulated Genome-Wide Distribution of Ancestral Chromosomal Segments. American Journal of Human Genetics. 2012, 91:849-862.
Shuhua Xu*. Human Population Admixture in Asia. Genomics & Informatics. 2012, 10(2):133-144.
Shuhua Xu*, Sanchit Guputa and Li Jin*. PEAS V1.0: A Package for Elementary Analysis of SNP Data. Molecular Ecology Resources. 2010, 10:1085-1088.
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The HUGO Pan-Asian SNP Consortium (Li Jin*, Edison T. Liu*, Mark Seielstad*, Shuhua Xu*; 93 authors from 10 countries). Mapping Genetic Diversity in Asia. Science. 2009, 326:1541-1545.
