Work Experience
Jean Krutmann was born in 1959 in Menden, Germany, and obtained his MD from the University of Münster in 1986. After several stays abroad (postdoc at Case Western Reserve University, Cleveland, Ohio, USA and DFG stipend at the University Hospital for Dermatology in Vienna, Austria) he became resident, assistant/associate professor at the University Hospital for Dermatology of Freiburg. From 1994 until 2001 he was full professor/deputy director of the University Hospital for Dermatology Düsseldorf. In 2001 he was appointed Chair of Environmental Medicine at the Medical Faculty of Heinrich Heine University Düsseldorf and thereby also Director of IUF. Under his directorship in 2011 the institute became a member of the Leibniz Association and was renamed IUF – Leibniz Research Institute for Environmental Medicine.
Research Interests
His research focuses on dermatology, immunodermatology and photodermatology with a special emphasis on environmentally-induced skin diseases and skin aging.
Selected Publications
1、Kamenisch, Y., Fousteri, M., Knoch, J., von Thaler, A. K., Fehrenbacher, B., Dolle, M., Kuiper, R., Marc Majora, M., Schaller, M., van Steeg, H., Röcken, M., Krutmann, J.* , Mullenders, L. H.*, Berneburg, M. (2010). Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J. Exp. Med. 207:379-390. *These authors contributed equally to this work PubMed
2、Sydlik, U., Gallitz, I., Albrecht, C., Abel, J., Krutmann, J.*, Unfried, K.* (2009). The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation. Am. J. Respir. Crit. Care Med. 180:29-35. * These authors contributed equally to this work PubMed
3、Grether-Beck, S., Salahshour-Fard, M., Timmer, A., Brenden, H., Felsner, I., Walli, R., Füllekrug, J., Krutmann, J. (2008). Ceramide and raft signaling are linked with each other in UVA radiation-induced gene expression. Oncogene 27:4769-4778. PubMed
4、Fritsche, E., Schäfer, C., Bernsmann, T., Calles, C., Wurm, M., Hübenthal, U., Cline, J. E., Schroe-der, P., Rannug, A., Klotz, L. O., Fürst, P., Hanenberg, H., Abel, J., Krutmann, J. (2007). Lightening up the UV response by identification of the Arylhydrocarbon Receptor as a cytoplasmatic target for ultraviolet B radiation. Proc. Natl. Acad. Sci. USA 104:8851-8856. PubMed
5、Schwarz, A., Ständer, S., Berneburg, M., Böhm, M., Kulms, D., van Steeg, H., Große-Heitmeyer, K., Krutmann, J., Schwarz, T. (2002). Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nature Cell Biol 4:26-31. PubMed
6、Grether-Beck, S., Bonnizi, G., Felsner, I., Timmer, A., Schmitt-Brenden, H., Sies, H., Johnson, J. P., Piette, J., Krutmann, J. (2000). Non-enzymatic triggering of the ceramide signaling cascade by solar ultraviolet A radiation. EMBO J. 19:5793-5800. PubMed
7、Stege, H., Roza, L., Vink, A. A., Grewe, M., Ruzicka, T., Grether-Beck, S., Krutmann, J. (2000). Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Proc. Natl. Acad. Sci. USA 97:1790-1795. PubMed
8、Morita, A., Werfel, T., Stege, H., Ahrens, C., Karmann, K., Grewe, M., Grether-Beck, S., Ruzicka, T., Kapp, A., Klotz, L. O., Sies, H., Krutmann, J. (1997). Evidence that singlet oxygen-induced human T-helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy. J. Exp. Med. 186:1763-1768. PubMed
9、Ahrens, C., Grewe, M., Berneburg, M., Grether-Beck, S., Quilliet, S., Mezzina, M., Sarasin, A., Lehmann, A. R., Arlett, C. F., Krutmann, J. (1997). Photocarcinogenesis and inhibition of ICAM-1 expression in cells of DNA-repair defective individuals. Proc. Natl. Acad. Sci. USA 94:6837- 6841. PubMed
10、Grether-Beck, S., Olaizola-Horn, S., Schmitt, H., Grewe, M., Jahnke, A., Johnson, J. P., Briviba, K., Sies, H., Krutmann, J. (1996). Activation of transcription factor AP2 mediates ultraviolet A radiation and singlet oxygen induced expression of the human ICAM-1 gene. Proc. Natl. Acad. Sci. USA 93:14586-14591. PubMed
