Work Experience
1. 2003-2008 Ph.D. of immunology at university of Science and Technology of China
2. 2009-2012 Postdoc of Biochemistry at Baylor College of Medicine
3. 2012-2015 Associate investigator, Investigator at Beijing Proteome Research Center
4. Since-2015 Investigator at Fudan University
Research Interests
Our lab has been focusing on developing novel MS-based proteomic methods to analyze dynamic changes of complex biological processes in a quantitative manner and made multiple contributions to the high-throughput, low-abundance, high-precision proteomics technology. We established one of the most efficient deep-coverage proteomics platform and the first one-stop proteomic data processing and integrated omics analysis cloud platform in the world, and invented transcription factor response elements on tip-mass spectrometry for quantitative measurement of endogenous transcription factors (TFs) DNA binding activity. We have a long-standing interest on a concept of “network analysis proteomics” based on signal transduction and transcriptional factors in intriguing biological processes such as organ development, cancer metastasis and aging. We are also developing the proteomics standard pipeline and applying the technologies in precision medicine and clinical research.
Principal Investigator of the current grants: (1) National Key R&D Program of China (2017YFA0505102); (2) National Key R&D Program of China (2017YFC0908404); (3) National Natural Science Foundation of China (31770886); (4) National Natural Science Foundation of China (31700682)
Awards
1. Beijing “High-level Oversea Young Talents” Project
2. Beijing “Outstanding Youth Scientists” Project
Selected Publications
1. Feng J#,Ding C#, *, Qiu N#, Ni X#, Zhan D#, Liu W, Xia X, Li P, Lu B, Zhao Q, Nie P, Song L, Zhou Q, Lai M, Guo G, Zhu W, Ren J, Shi T*, Qin J*. Firmiana: Towards a One-stop Proteomic Cloud Platform for Data Processiong and Analysis.Nat Biotechnol, 2017. doi: 10.1028/nbt.3825. (#Co-first author, *Co-corresponding author)
2. Zhou Q, Liu M, Xia X, Gong T, Feng J, Liu W, Liu Y, Zhen B, Wang Y,Ding C*, Qin J*. A mouse tissue transcription factor atlas.Nat Commun. 2017 Apr 21;8:15089. doi: 10.1038/ncomms15089. (*Co-corresponding author)
3. Lang X, Tang T, Jin T,Ding C*, Zhou R*, Jiang W*. TRIM65 Catalyzed Ubiquitination is Essential for MDA5-mediated Antiviral Innate Immunity.J Exp Med. 2017 Feb;214(2):459-473. doi: 10.1084/jem.20160592. Epub 2016 Dec 28 (*Co-corresponding author)
4. Foulds CE#, Feng Q#,Ding C#, Bailey S, Hunsaker TL, Malovannava A, Hamilton RA, Gates LA, Zhang Z, Li C, Chan D, Bajaj A, Callaway CG, Dean P. Edwards DP, Lonard DM, Tsai SY, Tsai MJ, Qin J, and Bert W. O’Malley BW. Proteomic Analysis of Coregulators Bound to ER on DNA and Nucleosomes Reveals Dynamic ‘Poised’ Complexes.Molecular Cell. 2013 Jul 25;51(2):185-99 (#Co-first author)
5.Ding C, Chan D, Liu W, Liu M, Li D, Li C, Jin J, Malovannaya A, Jung SY, Zhen B, Wang Y, Qin J. Proteome-wide profiling of activated transcription factors with a concatenated tandem array of transcription factor response elements.Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6771-6.
