Mei TianProfessor

Professor

Executive president, Human Phenome Institute, Fudan University

Email: tianmei@fudan.edu.cn

   Experience

Prof. Mei Tian is the Distinguished Professor of Fudan University, and President of World Molecular Imaging Society (WMIS). She has 25+ years post-MD training and practice in radiology, nuclear medicine and molecular imaging. Her group focuses on molecular imaging with a particular emphasis on human major diseases. Her current research interests include development of novel molecular imaging technologies and application in human phenomics, and human major diseases (aging and cancers). Prof. Tian’s group has developed precision PET imaging approach on pediatric epilepsy and MRI-negative pre-operative epilepsy. Furthermore, she has extended their research on brain-machine interface (BMI), internet gaming disorder (IGD), post-traumatic stress disorder (PTSD), etc., and continually to develop big data-based smart diagnosis for neuro-psychiatric disorders, including Epilepsy, AD, PD and others. Her group also develops novel molecular imaging agents or probes for precise theranostics.

Prof. Tian has made innovative and original contributions to the field of medical imaging, published extensively in international journals, such as Journal of Nuclear Medicine (JNM), European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI), Nature Biomediccal Engineering, PNAS, ACS Nano, Advanced Functional Materials, Biomaterials, Neuroimage, Science Translational Medicine, Clinical Cancer Research, etc., and won scholastic and scientific awards, such as National Distinguished Women Scientist Award, National Distinguished Young Scientist Award, Merit Award (RSNA), International Young Investigator Grant (RSNA), International Development and Education Grant (ASCO), Asian and Oceanian Distinguished Young Investigator Award (JSNM), JSPS fellowship (JSPS) for her extraordinary accomplishments, and selected as the Fellow of the World Molecular Imaging Society (WMIS).

Prof. Tian has made significant contribution to the field of molecular imaging in China and Asia. She is the founder and the President of the Hangzhou International Molecular Imaging Conference (HIMIC), which has been recognized as one of the most important international platform for communications and collaborations in Asia. She is the co-founder of the Molecular Imaging Center of Zhejiang University, who set up one of the largest and comprehensive training programs of molecular imaging in China. Prof. Tian has received many national major grants from the Ministry of Education (MOE), the Ministry of Science and Technology (MOST) and the National Science Foundation of China (NSFC) including the A3 foresight program grant, which is the core grant for international education and collaboration among China, Japan and Korea (A3), to setup a world-class research hub within the Asian Region, which will foster the next generation of talented young researcher in the field of molecular imaging.

Prof. Tian is serveing as the President of the World Molecular Imaging Society (WMIS), the Regional Editor of the Molecular Imaging and Biology, the nominating committee member of WMIS, session chairs of various categories in each year, and contributed a lot of time and efforts to the WMIS. In addition, Prof. Tian also serves as the Vice President and Committee Chair of Molecular Imaging, Chinese Society for Cognitive Science (CSCS), and the associate editor or editorial board members of the official journals of the WMIS, SNMMI, EANM, BSNM and JSNM, the editorial consultant of The LANCET, and the associate editor of Sensors and Diagnostics, the official journal of the Royal Society of Chemistry (RSC). She has been elected as the Fellows of WMIS and RSC.


publication

  1. Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M*, Liu X*. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances. 2022 Apr 15;8(15):eabk2376.

  2. Jin C, Luo X, Li X, Zhou R, Zhong Y, Xu Z, Cui C, Xing X, Zhang H*, Tian M*. Positron emission tomography molecular imaging-based cancer phenotyping. Cancer. 2022 Apr 13. doi: 10.1002/cncr.34228. Online ahead of print.

  3. Yu F, Li M, Wang Q, Wang J, Wu S, Zhou R, Jiang H, Li X, Zhou Y, Yang X, He X, Cheng Y, Ren X*, Zhang H*, Tian M*. Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model. Eur J Nucl Med Mol Imaging. 2022 Mar 19. doi: 10.1007/s00259-022-05764-2. Online ahead of print.

  4. Zhou R, Qin S, Cho W C. S., Zhou J, Jin C, Zhong Y, Wang J, Zhang X, Xu Z, Tian M*, Chan W.C*, Zhang H*. Microbiota-microglia connections in age-related cognition decline. Aging Cell. 2022 Mar 29;e13599.

  5. Zhang T, Li Y, Zhao S, Xu Y, Zhang X, Wu S, Dou X, Yu C, Feng J, Ding Y, Zhu J, Chen Z, Zhang H*, Tian M*. High-resolution pediatric age-specific 18F-FDG PET template: A pilot study in epileptogenic focus localization. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1560-1573.

  6. Zhang K, Mizuma H, Nakatani Y, Kanayama Y, Takahashi K, Matsumoto Y, Wada Y, Onoe K, Hayashinaka E, Wu Y, Zhang X, Tian M*, Zhang H*, Watanabe Y*. Neural correlates of beneficial effects of young plasma treatment in aged mice: PET-SPM analyses and neuro-behavioural/molecular biological studies. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1456-1469.

  7. Qin X, Jiang H, Liu Y, Zhang H*, Tian M*. Radionuclide Imaging of Apoptosis for Clinical Application. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1345-1359.

  8. Zhang X, Chen L, Jiang H, He X, Feng L, Ni M, Ma M, Wang J, Zhang T, Wu S, Zhou R, Jin C, Zhang K, Qian W, Chen Z, Zhuo C, Zhang H*, Tian M*. A novel analytic approach for outcome prediction in diffuse large B-cell lymphoma by [18 F]FDG PET/CT. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1298-1310.

  9. Liu Y, Jiang H, Qin X, Tian M*, Zhang H*. PET imaging of reactive astrocytes in neurological disorders. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1275-1287

  10. Tian M*, Civelek AC*, Carrio I, Watanabe Y, Kang KW, Murakami K, Garibotto V, Prior JO, Barthel H, Zhou R, Hou HF, Dou XF, Jin CT, Zuo CT, Zhang H*. International consensus on the use of tau PET imaging agent F-18-flortaucipir in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2022 Feb;49(3):895-904

  11. Li Y, Zhang T, Feng J, Qian S, Wu S, Zhou R, Wang J, Sa G, Wang X, Li L, Chen F, Yang H, Zhang H*, Tian M*. Processing Speed Dysfunction is Associated with Functional Corticostriatal Circuit Alterations in Childhood Epilepsy with Centrotemporal Spikes: A PET and fMRI Study. Eur J Nucl Med Mol Imaging. 2022 Feb 24. doi: 10.1007/s00259-022-05740-w. Online ahead of print.

  12. Huang H, Sun Z, Yang H, Yang X, Wu F, Sun Y, Li C*, Tian M*, Zhang H*, Wang Q*. Precise Examination of Peripheral Vascular Disease for Diabetics with a Novel Multiplexed NIR-II Fluorescence Imaging Technology. Nanotoday. 43(2022):101378.

  13. Ouyang J, Sun L, Pan J, Zeng Z, Zeng C, Zeng F*, Tian M*, Wu S*. A Targeted Nanosystem for Detection of Inflammatory Diseases via Fluorescent/Optoacoustic Imaging and Therapy via Modulating Nrf2/NF-kB Pathways. Small. 2021 Oct;17(42):e2102598.

  14. Tian M*, Watanabe Y, Kang KW, Murakami K, Chiti A, Carrio I, Civelek A.C, Feng J, Zhu Y, Zhou R, Wu S, Zhu J, Ding Y, Zhang K, Zhang H*. International consensus on the use of [18F]‑FDG PET/CT in pediatric patients affected by epilepsy. Eur J Nucl Med Mol Imaging. 2021 Nov;48(12):3827-3834.

  15. Jin C, Luo X, Qian S, Zhang K, Gao Y, Zhou R, Cen P, Xu Z, Zhang H*, Tian M*. Positron emission tomography in the COVID-19 pandemic era. Eur J Nucl Med Mol Imaging, 2021, 48(12):3903-3917.

  16. Li Y, Feng J, Zhang T, Shi K, Ding Y, Zhang X, Jin C, Pan J, Xue L, Liao Y, Wang X, Zhuo C, Zhang H*, Tian M*. Brain metabolic characteristics distinguishing typical and atypical benign epilepsy with centro-temporal spikes. Eur Radiol. 2021 Dec;31(12):9335-9345.

  17. Sun H, Zhong Y, Zhu X, Liao H, Lee J, Chen Y, Ma L, Ren J, Zhao M, Tu M, Li F, Zhang H, Tian M*, Ling D*. A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's disease. ACS Nano. 2021 Mar 23;15(3):5263-5275.

  18. Li X, Zhang K, He X, Zhou J, Jin C, Shen L, Gao Y, Tian M*, Zhang H*. Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder. Neuroscience Bulletin. 2021 Jul; 37(7):1051-1071.

  19. Zhang K*, Mizuma H, Zhang X, Takahashi K, Jin C, Song F, Gao Y, Kanayama Y, Wu Y, Li Y, Ma L, Tian M*, Zhang H*, Watanabe Y*. PET imaging of neural activity, β-amyloid, and tau in normal brain aging. Eur J Nucl Med Mol Imaging. 2021 Nov;48(12):3859-3871.

  20. Wang C, Sun W, Zhang J, Zhang J, Guo Q, Zhou X, Fan D, Liu H, Qi M, Gao X, Xu H, Gao Z, Tian M, Zhang H, Wang J, Wei Z, Long N, Mao Y*, Li C*. An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy. Nat Biomed Eng. 2021 Mar;5(3):278-289.

  21. Gao Y, Wu S, Pan J, Zhang K, Li X, Xu Y, Jin C, He X, Shi J, Ma L, Wu F, Yao Y, Wang P , He Q, Lan F*, Zhang H*, Tian M*. CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes. Eur J Nucl Med Mol Imaging. 2021 Mar; 48(3):708-720

  22. Tian M*, He X, Jin C, He X, Wu S, Zhou R, Zhang X, Zhang K, Gu W, Wang J, Zhang H*. Transpathology: molecular imaging based pathology. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2338-2350.

  23. Zhang Q, Liao Y, Wang X, Zhang T, Feng J, Deng J, Shi K, Chen L, Feng L, Ma M, Xue L, Hou H, Dou X, Yu C, Ren L, Ding Y, Chen Y, Wu S, Chen Z, Zhang H*, Zhuo C*, Tian M*. A Deep Learning Framework for 18F-FDG PET Imaging Diagnosis in Pediatric Patients with Temporal Lobe Epilepsy. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2476-2485.

  24. Zhang K, Sun Y, Wu S, Zhou M, Zhang X, Zhou R, Zhang T, Gao Y, Chen T, Chen Y, Yao X, Watanabe Y*, Tian M*, Zhang H*. Systematic imaging in medicine: a comprehensive review. Eur J Nucl Med Mol Imaging. 2021 Jun; 48(6):1736-1758.

  25. Cai X, Zhang K, Xie X, Zhu X, Feng J, Jin Z, Zhang H, Tian M*, Chen H*. Self-assembly hollow manganese Prterm sussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline. Biomaterials, 2020 Feb;231:119678

  26. Dong S, Zhao J, Zhang M, Shi Z, Deng J, Shi Y, Tian M, Zhuo C*. DeU-Net: Deformable U-Net for 3D Cardiac MRI Video Segmentation. MICCAI 2020: Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 pp 98-107.

  27. Du R, Zhu X, Wu , Zhang X, He Y, Zhang K, He X, Wang X, Sun Y, Wang Q, Zhang H*, Tian M*. PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2019 Oct;46(11):2392-2397.

  28. He X*, Ji J, Tian M, Esteva FJ, Hortobagyi GN, Yeung SJ*. Long-Term Survival Analysis of Adjuvant Chemotherapy with or without Trastuzumab in Patients with T1, Node-Negative HER2-Positive Breast Cancer. Clin Can Res. 2019 Dec 15; 25(24): 7388-7395.

  29. Zhang K, Tu M, Gao W, Cai X*, Song F, Chen Z, Zhang Q, Wang J, Jin C, Shi J, Yang X, Zhu Y, Gu W, Hu B, Zheng Y*, Zhang H*, Tian M*. Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis. Nano Lett. 2019 May 8;19(5):2812-2823.

  30. Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL*, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG*. MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2806-2811.

  31. Chen Q, Du Y, Zhang K, Liang Z, Li J, Yu H, Ren R, Feng J, Jin Z, Li F, Sun J, Zhou M, He Q, Sun X, Zhang H, Tian M*, Ling D*. Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease. ACS Nano. 2018 Feb 27;12(2):1321-1338.

  32. Ding Y, Zhu Y, Jiang B, Zhou Y, Jin B, Hou H, Wu S, Zhu J, Wang ZI, Wong CH, Ding M, Zhang H, Wang S, Tian M*. 18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2018 Jul;45(9):1567-1572.

  33. Zhu Y, Feng J, Ji J, Hou H, Chen L, Wu S, Liu Q, Yao Q, Du P, Zhang K, Chen Q, Chen Z, Zhang H, Tian M*. Alteration of monoamine receptor activity and glucose metabolism in  pediatric patients with anticonvulsant-induced cognitive impairment. J Nucl Med. 2017 Sep;58(9):1490-1497.

  34. Zhu Y, Feng J, Wu S, Hou H, Ji J, Zhang K, Chen Q, Chen L, Cheng H, Gao L, Chen Z, Zhang H, Tian M*. Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy. J Nucl Med. 2017 Aug; 58(8):1293-1299.

  35. Chen Q, Zhang Y, Hou H, Du F, Wu S, Chen L, Shen Y, Chao F, Chung JK, Zhang H, Tian M*. Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging. Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1033-1041.

  36. Wu S, Zhu Y, Liu H, Tang L, Du R, Shen Y, Feng J, Zhang K, Xu C, Zhang S, Chen Y, Song F, Zhu Y, Gu W, Liang P, Carrio I, Zhang H, Tian M*. In Vivo Dynamic Metabolic Changes After Transplantation of Induced Pluripotent Stem Cells for Ischemic Injury. J Nucl Med. 2016 Dec; 57(12):2012-2015.

  37. Zhu Y, Xu K, Xu C, Zhang J, Ji J, Zheng X, Zhang H, Tian M*. PET Mapping for Brain–Computer Interface Stimulation of the Ventroposterior Medial Nucleus of the Thalamus in Rats with Implanted Electrodes. J Nucl Med. 2016 Jul; 57(7):1141-1145.

  38. Zhu Y, Du R, Zhu Y, Shen Y, Zhang K, Chen Y, Song F, Wu S, Zhang H, Tian M*. PET mapping of neurofunctional changes in a posttraumatic stress disorder model. J Nucl Med. 2016 Sep; 57(9):1474-1477.

  39. Zhang H, Song F, Xu C, Liu H, Wang Z, Li J, Wu S, Shen Y, Chen Y, Zhu Y, Du R, Tian M*. Spatiotemporal PET Imaging of Dynamic Metabolic Changes After Therapeutic Approaches of Induced Pluripotent Stem Cells, Neuronal Stem Cells, and a Chinese Patent Medicine in Stroke. J Nucl Med. 2015 Nov; 56(11):1774-1779.