Work Experience
1. State Key Laboratory of Genetic Engineering, 2017-present, Deputy Director
2. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, 2016-present, Deputy Director
3. Collaborative Innovation Center of Genetics and Development, 2014-present, Deputy Director of Division of Genomics
4. Fudan University, China, 2011-present, Professor/Principal Investigator
5. Fudan University, China, 2009-2011, Associate Professor
6. Baylor College of Medicine, the United States, 2007-2009
7. Postdoctoral Associate; Mentor, Professor James R. Lupski
8. Fudan University, China, 2002-2007
9. Ph.D. in Genetics, July 2007; Mentor, Professor Li Jin
10. East China University of Science and Technology (ECUST), China, 1998-2002
11. Bachelor of Engineering in Biochemical Engineering, June 2002
Research Interests
Human genomic rearrangements; copy number variations (CNVs)/structural variations (SVs) and their roles in human diseases, e.g. birth defects and human infertility.
Awards
1. Outstanding Young Scholar, National Natural Science Foundation of China, 2016
2. Chang Jiang Young Scholar, Ministry of Education of China, 2015
3. Outstanding Achievements Award, WuXi PharmaTech Life Science and Chemistry Awards, 2015
4. 2015 Grand Challenges—Young Scientists, Bill & Melinda Gates Foundation, 2015
Selected Publications
1. Wu N*, Ming X*, Xiao J*, Wu Z*, Chen X*, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev ZS, Liu S, Yang N, Al-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Shen J, Chen Y, Zhang T, Zhang J, Choy KW, Wang J, Wang Q, Li S, Zhou W, Guo J, Wang Y, Zhang C, Zhao H, An Y, Zhao Y, Wang J, Liu Z, Zuo Y, Tian Y, Weng X, Sutton VR, Wang H, Ming Y, Kulkarni S, Zhong TP, Giampietro PF, Dunwoodie SL, Cheung SW, Zhang X, Jin L, Lupski JR, Qiu G#,Zhang F# (2015) TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis.New England Journal of Medicine372:341-350.
2. Chen L, Zhou W, Zhang C, Lupski JR, Jin L,Zhang F# (2015) CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis.Human Molecular Genetics24(6):1574-1583.
3. Sun Z, Liu P, Jia X, Withers MA, Jin L, Lupski JR,Zhang F# (2013) Replicative mechanisms of CNV formation preferentially occur as intrachromosomal events: evidence from Potocki-Lupski duplication syndrome.Human Molecular Genetics22(4):749-756.
4.Zhang F, Gu W, Hurles ME, Lupski JR (2009) Copy number variation in human health, disease, and evolution.Annual Review of Genomics and Human Genetics10:451-481.
5.Zhang F, Khajavi M, Connolly AM, Towne CF, Batish SD, Lupski JR (2009) The DNA replication FoSTeS/MMBIR mechanism can generate human genomic, genic, and exonic complex rearrangements.Nature Genetics41(7):849-853.
