Mengyao Yu Young Principal Investigator

 Work Experience

1、2020.11-Actual Research Professor, Human Phenome Institute, Fudan University

2、2020.11-Actual Platform Engineer, Department of Bioinformatics, Institute of Neuroscience, Chinese Academy of Science

3、2019.09-2020.09 Postdoctoral research fellow, School of Medicine, Stanford University

 Research Interests

1. Using multi-omics to study the genetic mechanisms of heart valve disease

2. Genetics of complex cardiovascular disease

 Selected Publications

1. Mengyao Yu, Catherine Tcheandjieu, Adrien Georges, et.al., Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease. JCI Insight. 2022;7(3):e146580.

2. Carolina Roselli, Mengyao Yu, Victor Nauffal, et.al., Genome-wide Association Study reveals Novel Genetic Loci and Polygenic Risk Score for Mitral Valve Prolapse. Eur Heart J. 2022 May 1;43(17):1668-1680.

3. Mengyao Yu, Sergiy Kyryachenko, Stephanie Debette, et.al., Genome-wide association meta-analysis supports genes involved in valve and cardiac development to associate with mitral valve prolapse. Circ Genom Precis Med. 2021 Aug 31:CIRCGEN120003148.

4. Sergiy Kyryachenko*, Adrien Georges*, Mengyao Yu*, et.al., Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. Circ Res. 2021 Mar 5;128(5):e84-e101.

5. Hafid Ait-Oufella*, Mengyao Yu*, Adrien Georges, et. al., Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study. Int J Cardiol. 2021 Dec 1;344:213-219.

6. Mengyao Yu, Adrien Georges, Nathan R. Tucker, et.al., Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. 2019 May;12(5):e002497.

7. Katelynn Toomer*, Mengyao Yu*, Diana Fulmer*, et.al., Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 May 22;11(493).