工作经历
1997年6月获得安徽师范大学化学系学士学位，2002年6月在中国科学院上海药物研究所获得有机化学博士学位后留所担任助理研究员，2004年9月-2006年6月在美国伊利诺伊大学芝加哥分校从事博士后研究，2006年7月-2009年4月在制药公司担任高级研发主管，2009年5月起在复旦大学药学院任教，2019年5月加入人类表型组研究院。
研究方向
从事药物表型组学研究，和心脑血管疾病、炎症性肠病等治疗药物的设计、合成及成药性研究。主持国家自然科学基金，科技部新药创制重大专项子课题等省部级基金13项；已发表SCI论文60余篇；已授权国内专利15项、美国专利1项。其中化药1.1类抗肿瘤新药喜诺替康（ZL 03142241.1）原料药和注射剂于2011年分别获得临床试验批件（2011L00694，2011L00695），并已转让给江苏正大天晴药业股份有限公司实现成果转化。
获奖情况
2012年获得上海药学科技奖二等奖(第3完成人)。
招生专业
药物化学
代表论文
1. Mei-Lin Tang, Xiao-Yu Xiong, Heyanhao Zhang, Yun-Zhi Wang, Rong-Qian Cheng, Jian-Ping Zuo, Lin Jin*, Ze-Min Lin*, Jun Chang*. From hit to lead: Discovery of first-in-class furanone glycoside D228 derived from Chimonanthus salicifolius for the treatment of inflammatory bowel disease. Journal of Medicinal Chemistry. 2024, 67, 17101-17123.
2. Ganfei Xu, Juan Yu, Jiacheng Lyu, Mengna Zhan, Jie Xu, Minjing Huang, Rui Zhao, Yan Li, Jiajun Zhu, Subei Tan, Peng Ran, Zhenghua Su, Xinhua Liu, Jianyuan Zhao, Hongwei Zhang*, Chen Xu*, Jun Chang*, Yingyong Hou*, Chen Ding*. Proteogenomic landscape of breast ductal carcinoma reveals tumor progression characteristics and therapeutic targets. Advanced Science. 2024, DOI: 10.1002/advs.202401041.
3. Jinghuan Wang#, Subei Tan#, Yuyu Zhang, Jie Xu, Yuhui Li, Qianwen Cheng, Chen Ding*, Xinhua Liu*, Jun Chang*. Set7/9 aggravates ischemic brain injury via enhancing glutamine metabolism in a blocking Sirt5 manner. Cell Death & Differentiation 2024, 31, 511-523.
4. Wen Zhong, Ye-jun Dong, Chen Hong, Yu-hui Li, Chen-xi Xiao, Xin-hua Liu*, Jun Chang*. ASH2L upregulation contributes to diabetic endothelial dysfunction in mice through STEAP4-mediated copper uptake. Acta Pharmacologica Sinica 2024, 45, 558-569.
5. Heyanhao Zhang, Jintao He, Rongqian Cheng, Huanren Yan, Mei-Lin Tang, Jun Chang*. Optimization for the Preparation of Procyanidin B3: Strategy for Gram-Scale and Stereoselective Formation of 4,8-Interflavan Bonds. Organic Process Research & Development 2024, 28(7), 2958-2971.
6. Jinghuan Wang, Qianwen Cheng，Yuyu Zhang，Chen Hong, Jiayao Liu, Xinhua Liu*, Jun Chang*. PARP16-mediated stabilization of amyloid precursor protein mRNA exacerbates Alzheimer’s disease pathogenesis. Aging and Disease 2023, 14(4), 1458-1471.
7. Mei-Lin Tang, Jin-Feng Ning, Yu-Hui Li, Heyanhao Zhang, Mi Liu, Ye-Jun Dong, Jun Chang*. Sulfoxide-mediated approach to flavones through one-pot Knoevenagel condensation/oxa-Michael addition/sulfoxide elimination process of β-(o-hydroxyaryl)-ketosulfone with arylaldehydes. Tetrahedron Letters 2023, 116, 154336.
8. Mei-Lin Tang, Zi-Hao Wen, Jing-Huan Wang, Mei-Ling Wang, Heyanhao Zhang, Xin-Hua Liu, Lin Jin*, Jun Chang*. Discovery of pyridone-substituted triazolopyrimidine dual A2A/A1 AR antagonists for the treatment of ischemic stroke. ACS Medicinal Chemistry Letters. 2022, 13, 436-442.
9. Heyanhao Zhang, Lin Jin, Ju-Bao Zhang, Tong Niu, Tao Guo*, Jun Chang*. Chemical constituents from the bulbs of Lilium davidii var. unicolor and anti-insomnia effect. Fitoterapia 2022, 161, 105252.
