工作经历
2025.3-今：特聘教授，博士生导师，复旦大学表型研究中心。
2018.8-今：终身教授，博士生导师，南洋理工大学李光前医学院；新加坡国家表型组中心主任；英国帝国理工名誉教授
2007年12-2018.7：研究员，博士生导师，中科院国外引进人才“项目百人”计划，中国科学院武汉物理与数学研究所
2001年7月-2007年11月：Research Fellow (RA2)，英国（伦敦大学）帝国理工学院生物医学部生物化学系。
1999年5月-2001年7月：博士后，英国生物技术及生命科学研究基金委员会-食品研究所
1998年5月-1999年4月: 博士后， 英国生物技术及生命科学研究基金委员会-植物研究所（John Inners Center, Norwich）
1994年10月-1997年10月：博士研究，英国生物技术及生命科学研究基金委员会(BBSRC)-食品研究所)/University of East Anglia
1991年2月-1993年1月：硕士研究, Northampton University College（Research assistant leading to higher degree, Grade: T.RB.2).
1986年9月-1990年3月：助理工程师，陕西省宝鸡市皮革厂。主要负责质量管理。
1982年9月-1986年7月：学士，西北轻工业学院。
曾主持或完成科技部973项目、中科院“知识创新工程”重要方向新项目、国家基金、国家创新群体等课题多项。迄今在PNAS等上发表SCI论文190余篇，被SCI论文引用万余次，H-index为62。应邀撰写英文著作10余章，在国际重要学术会议上做邀请报告几十次，出版著作1部。现任Phenomics, Scientific Reports、Metabolomics等国际学术期刊编委、中国生物物理学会生物磁共振专业委员、中国营养学会常务理事。曾任国际核磁共振领域最有影响的Experimental Nuclear Magnetic Resonance Conference（ENC）的第一位亚洲执委(中国两岸三地的唯一)， 2015年获全国“五一巾帼标兵”称号。
研究方向
代谢组分析方法的开发：利用核磁共振和质谱相结合的分析方法发展高灵敏、全覆盖的代谢组学方法。
研究肠道菌群代谢：研究肠道菌群代谢以及饮食、疾病影响肠道菌群，进而影响健康的代谢机制。
招生专业
生物学（报考方向：生物化学与分子生物学/分子表型代谢组学） 生物与医药（报考方向：表型组学新技术开发及应用）
获奖情况
2022：李光前医学院院长奖
2021：上海领军人才计划
2015：中华全国总工会全国五一巾帼标兵
2008：科学院“项目百人”计划
代表论文
1、X.T. Wu, J.A. Miller, B.T.K.W. Lee, Y.L. Wang, C. Ruedl, “Reducing microglial lipid load enhances beta-amyloid phagocytosis and efferocytosis in an 3 Alzheimer’s disease mouse model”, Science Advances, 11(6), wadq6038, Feb. 2025. 1A+
2、S.J. Ma, L.T. Ong, Z.M. Jiang, W. C. Lee, P.L. Lee, Q.F. chen, H.J. Ditzel, W.Y. Wang, X.J. Wu, E.Y. Tan, Y.L. Wang, Qiang Yu, “Targeting P4HA1 promotes CD8 T cell progenitor expansion towards immune memory and systemic antitumor immunity”, Cancer Cell, 43(2): 213-231 Oct, 2024 doi: 10.1016/j.ccell.2024.12.001 1A+
3、T.L. Boye, A.Hammerhoj, O.H. Nielsen*, Y.L. Wang, “Metabolomics for enhanced clinal understanding of inflammatory bowel disease” Life Sciences, 359, 123238, 2024, https://doi.org/10.1016/j.lfs.2024.123238. IF=5.2
4、Y.T. Sun, Q.Y. Hu, J.L. Zuo, H. Wang, Z.D Guo, Y.L. Wang*; H.R. Tang,* “Simultaneous quantification of carboxylate enantiomers in multiple human matrices with the hydrazide-assisted ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry”. Analytical Chemistry, 96, 18141-18149, Oct. 2024, DOI: 10.1021/acs.analchem.4c04187 1A+
5、W.R. Li, C.H. Lim, Z.T. Zhao, Y.L. Wang, P.L. Conway, S.C.J. Loo*, “In Vitro Profiling of Potential Fish Probiotics, Enterococcus hirae strains, Isolated from Jade Perch, and Safety Properties Assessed Using Whole Genome Sequencing”, Probiotics and Antimicrobial Proteins. March, 2024, 10.1007/s12602-024-10244-0. 1B
6、Y.L. Zhou, C. Qu, H.L. Yan, T.Z. Chu, J. Wu, Q.Z. Kang, C. Peng*, Y.L. Wang*, Y.Z. Tan*, “Unlocking the hidden potential: Enhancing the utilization of stems and leaves through metabolite analysis and toxicity assessment of various parts of Aconitum carmicharlii”, Journal of Ethnopharmacology, Jan. 323, 117693, 2024. 10.1016/j.jep.2023.117693.1B
7、J.F. Wu*, Q.Y. Hu, X.P. Rao, H.Y. Zhao, H.R. Tang, Y.L. Wang*, “Gut microbiome and metabolic profiles of mouse model for MeCP2 duplication syndrome”, Brain Research Bulletin, Jan, 2024, 206:110862, https://doi.org/10.1016/j.brainresbull.2023.110862.
8、J. Zheng, J.J. Yang, X. Liang, M.L. Fang*, Y.L. Wang*, "Dual Strategy for 13C-metabolic flux analysis of central carbon and energy metabolism in mammalian cells based on LC-sioMRM-MS", Talanta, 1;266(Pt2), 125074, Jan 2024, https://doi.org/10.1016/j.talanta.2023.125074 1B
9、C.C. Zhang, L. Xu, Q.X. Huang, Y.L. Wang, H.R. Tang*, “Detecting submicromolar analytes in mixtures with a 5 min acquisition on 600 MHz NMR spectrometers”, Journal of the American Chemical Society, 145, 47, 25513-25517, Dec. 2023, 10.1021/jacs.3c07861.
10、E. Fung, E.Y.S. Chan, K.H. Ng, K.M. Yu, H.J. Li, Y.L. Wang, “Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates”, Journal of Inflammation, 20:32, 2023, Oct, DOI: 10.1186/s12950-023-00358-7
11、J. Zheng, J.J. Yang, F.R. Zhao, B. Peng, Y.L. Wang*, M.L. Fang*, “CIL-ExPMRM: An Ultrasensitive Chemical Isotope Labeling Assisted Pseudo-MRM Platform to Accelerate Exposomic Suspect Screening”, , Environmental Science and Technology, 57, 30, 10962-10973, 2023, July https://doi.org/10.1021/acs.est.3c01830
12、Q.Y. Hu, Y.T. Sun, X.Y. Mu, Y.L. Wang*, H.R. Tang*, “Reliable quantification of citrate isomers and isobars with direct-infusion tandem mass spectrometry”. 2023, July, 259, 124477, Talanta, https://doi.org/10.1016/j.talanta.2023.124477.
13、C.Y. Huang, H.H. Lei, C.Y. Liu, Y.L. Wang*, “Acute and subchronic exposure of cyadox induced metabolic and transcriptomic disturbances in Wistar rats”, Toxicology, 482, DOI10.1016/j.tox.2022.153367, Nov. 2022.
14、J.T. Bjerrum,* Y.L. Wang*, J.T. Zhang, L.B. Rils, O.H. Nielsen, J.B. Seidelin “Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets”. International Journal of Biological Sciences, 18(5) 1813-1828, 2022, doi: 10.7150/ijbs.67112 13-04/2022 Feb
15、Q.Y. Hu, Y.T. Sun, P.H. Yuan, H.H. Lei, H.Q. Zhong, Y.L. Wang*, H.R. Tang*, “Quantitative structure-retention relationship for reliable metabolite identification and quantification in metabolomics using ion-pair reversed-phase chromatography coupled with tandem mass spectrometry”, Talanta, 238, 23059, 2022. https://doi.org/10.1016/j.talanta.2021.123059. Feb
16、J.H. Ch’ng, M. Muthu, K.K.L. Chong, J.J. Wong, C.A.Z. Tan, Z.J.S. Koh, D. Lopez, A. Matysik, Z.J. Nair, T. Barkham, Y.L Wang, K.A. Kline, “Heme cross-feeding can augment Staphylococcus aureus and Enterococcus faecalis dual species biofilms” The ISME Journal, 2022, https://doi.org/10.1038/s41396-022-01248-1. May
17、X.Y. Zhu, Y.Y. Guo, Z.G. Liu, J.Y. Yang, H.R. Tang, Y.L. Wang*, “Itaconic acid Exerts Anti-inflammatory and Bactericidal Effects via Promoting Pentose Phosphate Pathway”. Scientific Reports, 11:18173, 2021, oi.org/10.1038/s41598-021-97352-x.
18、L.C. Zhang, T.F. Xu, J.T. Zhang, S.C.C. Wong, M. Ritchie, H.W. Hou, Y.L. Wang*, “Single Cell Metabolite Detection Using Inertial Microfluidics-Assisted Ion Mobility Mass Spectrometry”, Analytical Chemistry, 93(30), 10462-10468, 2021, Aug, DOI: 10.1021/acs.analchem.1c00106
19、Y.Q. Goh, G.X. Cheam, Y.L.Wang*, “Understanding choline bioavailability and utilization: First step toward personalizing choline nutrition”, Journal of Agricultural and Food Chemistry, 9(37) 1077-1089, 2021. Sept. https://doi.org/10.1021/acs.jafc.1c03077 Front cover paper
20、Y. Sun, H.R. Tang, Y.L. Wang*, “Progress and Challenges in Quantifying Carbonyl-Metabolomic Phenomes with LC-MS/MS”, Molecules, 26 (20), 6147, 2021. doi.org/10.3390/molecules26206147.
21、S.S. Adav, Y.L. Wang*, Metabolomics signatures of Aging: Recent Advances, Aging and Disease, 12, 646-661, 2021, April, DOI: 10.14336/AD.2020.0909.
22、L.F. Ding, C.C. Zhang, Z.G. Liu, Q.X. Huang, Y.L. Zhang, G.J. Nie, H.R. Tang, Y.L. Wang*, “Metabonomics investigation of biological effects of a new vessel target protein tTF-pHLIP in a mouse model”, Journal of Proteome Research, 19, 238-247, 2020. DOI: 10.1021/ACS.JPROTEOME.9B00507.
23、Q.Y. Hu, H.R. Tang, Y.L. Wang*, “Challenges in analysis of hydrophilic metabolites using chromatography coupled with mass spectrometry”. Journal of Analysis and Testing, 4, 140-162, 2020. DOI 10.1007/s41664-020-00126-z.
24、J.F. Wu*, X.H. Zhu, H. Lin, Z.L. Chen, H.R. Tang, Y.L. Wang*, “Gender differences in the bile acid profile of APP/PS1 transgenic AD mice”. Brain Research Bulletin. 2020, 161, 116-126. doi.org/10.1016/j.brainresbull.2020.05.003.
25、L.W. Chen, J.T. Zhang, T.P. Jean, B.K. Cheon, Y.F. Yang, J. Schlundt, Y.L. Wang, P.L. Conway*,“Comparative blood and urine metabolomics analysis of healthy elderly and young male Singaporeans” Journal of Proteome Research. 19, 8, 3264-3275, 2020, doi.org/10.1021/acs.jproteome.0c00215
