工作经历
复旦大学特聘教授 博士生导师 国家重点研发计划首席科学家 上海市优秀学术带头人。获医学学士、硕士学位、物理学博士学位（复旦大学与美国田纳西大学联合培养，博士后身份），复旦大学卫生管理学博后。曾担任中科院上海高等研究院（2011-2019）研究员 博导 课题组长 实验室主任 院学术委员会委员；中科院上海微系统所（2019-2025）研究员 博导 课题组长 所战略顾问委员；目前为复旦大学人类表型组研究院教授 负责搭建微全流控测量与类器官等技术平台并开展研究。
发表一作/通信论文90余篇；其中7篇发表在Biosensors and Bioelectronics上， 2篇发表在 Analytical Chemistry，3篇发表在Appl Mater Interfaces,2篇发表在Materials Today Bio上，3篇发表在Microsystems and nanoengineering；论文还发表在PNAS ,Sensors and Actuator B : Chemical等。含封面3篇（PNAS 2005，102 (49):17630-1763, Lab on Chip,2019,19,3405–3415，Anal Chem 2023，13;95(23):8889-8897）、年度亮点1篇（Nanoscale 2015,7(38):15822-15829），ESI 1%高被引1篇（Biosensors and Bioelectronics. 2017,89(Pt 1):96-106）。其中电化学传感器成果被中科院院网(标题：上海微系统所在基于基因序列编辑器的电化学传感器研究方面取得进展,Biosensors and Bioelectronics.2022;217:114671)报道，外泌体miRNA荧光检测成果分别被中科院院网、上海市政府网站报道(标题：上海微系统所在外泌体miRNA原位荧光检测技术方面取得进展,Biosensors and Bioelectronics.2022,204：114077)。申请发明专利44项，获授权14项（10项第1）, 申请实用专利11项（授权10项），获软件著作权3项。 担任两轮中欧医疗器械专家圆桌会议专家组组长，是亚洲医疗器械协调组织（AHWP）技术委员，ISO/TC 276/SC 2（Microphysiological systems and Organ-on- Chip）/WG 1工作组专家。
研究方向
集中在人类表型组与生物医学工程学交叉；方向为微流控表型检测、类器官芯片及生物医学工程产品研发；研究专长侧重于（1）微全表型测量：包括生物纳米探针、生物检测芯片、原位传感成像技术、量子探测器等；（2）类器官芯片：包括肿瘤免疫微环境芯片、多器官串联芯片、液滴阵列芯片等；（3）微流控纳米药物制备：靶向药物、组合药物等；（4）数据与规范：包括数据智能汇交、智能控制分析等；芯片、类器官等新技术涉及的合规性问题等。
招生专业
生物学（研究方向：生物编码探针、微流控芯片、微纳表型测量以及监管科学技术）
代表论文
1 Long Chen, Yi Xu, Lele Zhou, Ding Ma, Rong Zhang, Yifan Liu and Xianqiang Mi*. Ultra-Sensitive Fluorescence-Activated Droplet Sorting Enabled by Tetramer Hybridization Chain Reaction. Microsystems & Nanoengineering 2025, 11:10.
2 Xiaoshuang Zhao, Jieying Zhang, Yifan Chen, Ziting Chen, Zhe Liu, Yi Xu, Xingjun Zhu, Yang Li, Xianqiang Mi*. Ouantum Dots Encoded Superparamagnetic Micon-particles Based on Layer-by-layerAssembly for Multiplexed Nucleic Acid Detection. Talata 2025, 13(293): 128109.
3 Ding Ma, Yaojun Wang,Yi Xu, Chang Chen, Xianqiang Mi*. Cascaded Logic Gate Based Electrochemical Analysis of Multiple miRNAs for Cancer Recognition. Biosensors and Bioelectronics 2025, 282, 117468.
4 Xiaoshuang Zhao, Ziting Chen, Chengren Tang, Xianqiang Mi*. Encoding fluorescence intensity with tetrahedron DNA nanostructure based FRET effect for bio-detection. Biosensors and Bioelectronics 2024, 248, 115994.
5 Yi Xu, Chenguang Wang, Ning Wu,* and Xianqiang Mi*. Development of an Electrochemical Microfluidic System with a Nanoscale Deoxyribonucleic Acid Framework for Detection of Circulating Tumor Cells. ACS Applied Nano Materials 2024, 7, 14, 15950-15957.
6 Shijie Lu, Ding Ma and Xianqiang Mi*. A High-Throughput Circular Tumor Cell Sorting Chip with Trapezoidal Cross Section. Sensors 2024, 24, 3552.
7 Long Chen, Yi Zhao, Jie Li, Chenwei Xiong, Yi Xu, Chengren Tang, Rong Zhang, Jingwei Zhang, Xianqiang Mi*, Yifan Liu. Exceeding 80% efficiency of single-bead encapsulation in microdroplets through hydrogel coating-assisted close-packed ordering. Analytical Chemistry 2023, 13, 95(23): 8889-8897.
8 Qiuling Qian, Yutong Wei, Yi Xu, Mengmeng Zheng, Chenguang Wang, Shulin Zhang, Xiaoming Xie, Chaofeng Y, Xianqiang Mi*.Microfluidic Magnetic Detection System Combining with DNA Framework Mediated Immune-sandwich Assay for Rapid and Sensitive Detection of Tumor-derived Exosomes. Microsystems & Nanoengineering 2023, 9: 139.
9 Yi Xu, Shuainan Li, Chenguang Wang, Xiaoming Xie, Xianqiang Mi*. μF-hBBB Chip Together with Tetrahedral DNA Frameworks for Visualization of LPS-Mediated Inflammation. Analytical Chemistry 2023, 95(30): 11449-11455.
10 Xiaoshuang Zhao, Yi Xu, Xianqiang Mi*. Fluorescence intensity coded DNA frameworks based on the FRET effect enable multiplexed miRNA imaging in living cells. Analytical Methods 2023, 15(25): 3051-3056.
11 Yi Xu, Chenguang Wang, Gang Liu, Xiaoshuang Zhao, Qiuling Qian, Shuainai Li, Xianqiang Mi*. Tetrahedral DNA framework based CRISPR electrochemical biosensor for amplification-free miRNA detection. Biosensors and Bioelectronics 2022, 217, 114671.
12 Chenguang Wang, Yi Xu, Shuainan Li，Yi Zhou, Qiuling Qian, Yifan Liu，Xianqiang Mi*. Designer Tetrahedral DNA Framework-Based Microfluidic Technology for Multivalent Capture and Release of Circulating Tumor Cells. Materials Today Bio 2022, 16:100346.
13 Chenwei Xiong, Jie Li, Luyao Li, Long Chen, Rong Zhang Xianqiang Mi*, Yifan Liu. Label-free electrical monitoring of nucleic acid amplification with integrated hydrogel ionic diodes. Materials Today Bio 2022, 15:100281.
14 Shuainan Li, Chenguang Wang, Yi Xu, Wei Wang, Xiaoshuang Zhao, Qiuling Qian and Xianqiang Mi*. A designer DNA tetrahedron-based molecular beacon for tumor-related microRNA fluorescence imaging in living cells. Analyst 2022, 147, 2231-2237.
15 Qiuling Qian, Guifang He, Chenguang Wang, Shuainan Li, Xiaoshuang Zhao, Yi Xu, Xianqiang Mi*. Poly‐adenine‐mediated spherical nucleic acid probes for live cell fluorescence imaging of tumor‐related microRNAs. Molecular Biology Reports 2022, 49:3705-3712.
16 Dongsheng Mao, Mengmeng Zheng, Wenxing Li, Yi Xu, Chengguang Wang, Qiuling Qian, Shuainan Li, Guifang Chen, Xiaoli Zhu, Xianqiang Mi*. Cubic DNA nanocage-based three-dimensional molecular beacon for accurate detection of exosomal miRNAs in confined spaces. Biosensors and Bioelectronics 2022, 204:114077.
17 Chenguang Wang ,Wei Wang ,Yi Xu, Xiaoshuang Zhao, Shuainan Li, Qiuling Qian and Xianqiang Mi*. Tetrahedral DNA Framework-Programmed Electrochemical Biosenors with Gold Nanoparticles for Ultrasensitive Cell-Free DNA Detection. Nanomaterials 2022, 12, 666.
18 Chenguang Wang,Yi Xu, Xiaoshuang Zhao, Shuainai Li, Qiuling Qian, Wei Wang and Xianqiang Mi*. A double-tetrahedral DNA framework based electrochemical biosensor for ultrasensitive detection and release of circulating tumor cells. Analyst 2021, 146(21): 6474-6481.
19 Dezhi Feng, Jing Su, Yi Xu, Guifang He, Chenguang Wang, Xiao Wang, Tingrui Pan, Xianting Ding,Xianqiang Mi*. DNA tetrahedron mediated immune sandwich assay for rapid, sensitive, and automatic detection of PSA through microfluidic electrochemical detection system. Microsystems & Nanoengineering 2021, 7:33.
20 Yi Zhang, Wei Jiang, Dezhi Feng, Chenguang Wang, Yi Xu , Yufeng Shan, Jianlu Wang , Ziwei Yin, Huiyong Deng,*, Xianqiang Mi* and Ning Dai,* Bio-Separated and Gate-Free 2D MoS2 Biosensor Array for Ultrasensitive Detection of BRCA1. Nanomaterials 2021, 11, 545.
21 Yi Zhang, Dezhi Feng, Yi Xu, Ziwei Yin, Wei Dou, UM E Habiba, Changyi Pan, Zongkun Zhang, Hao Mou, Huiyong Deng*, Xianqiang Mi*, Ning Dai. DNA-based functionalization of two-dimensional MoS2 FET biosensor for ultrasensitive detection of PSA. Applied Surface Science 2021, 548, 149169.
22 HuanZhang*, XinxinLiu, ChunxiuZhang, YiXu, JingSu, Xiaoliang Lu, JiyeShi, LihuaWang, Markita P.Landry, YingZhu, Min Lv*, XianqiangMi*. A DNA Tetrahedral Structure-Mediated Ultrasensitive Fluorescent Microarray Platform for Nucleic Acids Tests. Sensors and Actuator B: Chemical 2020, 321: 128538.
23 Dezhi Feng,Jing Su,Guifang He, Yi Xu,Chenguang Wang,Mengmeng Zheng,Qiuling Qian,Xianqiang Mi*. Electrochemical DNA Sensor for Sensitive brca1 Detection Based on DNA Tetrahedral-Structured Probe and Poly-Adenine Mediated Gold Nanoparticles. Biosensors 2020, 10:78.
24 Dongdong Zeng, Lili San, Fengyu Qian, Zhilei Ge, Xiaohui Xu, Bin Wang, Qian Li, Guifang He, Xianqiang Mi*. Framework Nucleic Acid-Enabled Programming of Electrochemical Catalytic Properties of Artificial Enzymes. ACS Applied Material&Interfaces. 2019, 11(24):21859-21864.
25 Xiao Wang, Jing Su, Dongdong Zeng, Gang Liu, Lizhuang Liu, Yi Xu, Chenguang Wang, Xinxin Liu, Lu Wang, Xianqiang Mi*. AuNFs flower modified disposable 16-SPCE electrochemical biosensor for label-free and multiplex detection of Glycated hemoglobin.Tanlanta 2019, 201, 119-125 .
26 Lu Wang, Huan Zhang, Chenguang Wang, Yi Xu, Jing Su, Xiao Wang, Xinxin Liu, Dezhi Feng, Lihua Wang, Xiaolei Zuo, Jiye Shi, Zhilei Ge, Chunhai Fan, Xianqiang Mi*. Poly-adenine-mediated Spherical Nucleic Acids for Strand Displacement-based DNA/RNA Detection. Biosensors and Bioelectronics 2019, 127:85-91.
27 Huan Zhang, Honglu Zhang, Ali Aldalbahi, Xiaolei Zuo, Chunhai Fan, Xianqiang Mi*. Fluorescent biosensors enabled by graphene and graphene oxide. Biosensors and Bioelectronics 2017, 89, 96-106. (影响因子10. 7, 被web of science评为本领域最优秀的1%)
28 Dongdong Zeng, Zehua Wang, Zhiqiang Meng, Peng Wang, Lili San, Wei Wang, Ali Aldalbah, Li Li, Juwen Shen*, and Xianqiang Mi*. DNA Tetrahedral Nanostructure-Based Electrochemical miRNA Biosensor for Simultaneous Detection of Multiple miRNAs in Pancreatic Carcinoma. ACS Appl Mater Interfaces 2017, 9(28):24118-24125.
29 Lili San, Dongdong Zeng, Shiping Song, Xiaolei Zuo, Huan Zhang, Chenguang Wang, Jiarui Wu, Xianqiang Mi*. An electrochemical immunosensor for quantitative detection of ficolin-3. Nanotechnology 2016, 27(25):254003.
30 Chenguang Wang, Huan Zhang, Dongdong Zeng, Lili San, Xianqiang Mi*. DNA nanotechnology mediated gold nanoparticle conjugates and their applications in biomedicine. Chinese Journal of Chemistry 2016, 34(3):299-307.
31 Huan Zhang , Yunsheng Wang, Daiwei Zhao, Dongdong Zeng, Jiaoyun Xia, Ali Aldalbahi, Chenguang Wang, Lili San, Chunhai Fan , Xiaolei Zuo, Xianqiang Mi*. Universal fluorescence biosensor platform based on graphene quantum dots and pyrene-functionalized molecular beacons for detection of microRNAs. ACS Appl Mater&Interfaces 2015, 7, 16152-16156（影响因子8.3)
32 Chenguang Wang , Huan Zhang, Dongdong Zeng , Wenliang Sun , Honglu Zhang, Ali Aldalbahi , Yunsheng Wang, Lili San, Chunhai Fan, Xiaolei Zuo, Xianqiang Mi*. Elaborately designed diblock nanoprobes for simultaneous multicolor detection of microRNAs. Nanoscale 2015,7(38): 15822-15829.（被评为年度“hot paper”）
33 Dongdong Zeng, Huan Zhang, Dan Zhu, Jiang Li, Lili San, Zehua Wang, Chenguang Wang, Yunsheng Wang, Lihua Wang, Xiaolei Zuo, Xianqiang Mi*. A novel ultrasensitive electrochemical DNA sensor based on double DNA tetrahedral nanostructures. Biosensors and Bioelectronics 2015, 71: 434-438.（累计引用66）
