徐书华教授，博士生导师

 个人简介

无党派人士；2006年博士毕业于复旦大学，同年入职中科院-马普学会计算生物学伙伴研究所，历任助理研究员、副研究员、研究员；2009年建立群体基因组学研究组（PGG）；2012-2018年担任德国马普学会和中科院共同支持的青年科学家小组组长；2013年兼任上海科技大学特聘教授；2015年任中科院特聘研究员（核心骨干）、获国家杰出青年基金；2016年入选上海市优秀学术带头人；2018年兼任中科院动物进化与遗传前沿交叉卓越创新中心特聘研究员、入选科技部中青年科技创新领军人才；2019年获英国皇家学会牛顿高级访问学者基金资助；2021年7月入职复旦大学任特聘教授，建立人类群体组学实验室（POG）。兼任中国遗传学会理事、上海市遗传学会常务理事、上海市人类学会理事；兼任多个SCI学术期刊编委如Molecular Genetics and Genomics 共同主编、Scientific Reports、Human Genomics、Hereditas、BMC Genomic Data资深编辑（Senior Editor）。

 研究方向

群体组学/人类遗传/分子进化/生物信息学/计算生物学

发展和运用群体遗传学方法和计算生物学手段，致力于研究人群遗传结构、环境适应和微观进化等方面的科学问题；在Science, Cell, PNAS, Nature Genetics, Nature Communications, Genome Biology, The American Journal of Human Genetics, Nucleic Acids Research, Genome Research, Molecular Biology and Evolution等期刊共发表SCI收录学术论文100多篇、被引用4600多次、单篇最高被引用570次以上。承担国家自然基金委重大研究计划集成项目、重点项目、面上项目、新冠应急专项、中科院先导专项、上海市市级重大专项、科技部重点研发计划等研究课题；曾获中科院青年科学家奖、中科院院长奖（导师）、教育部自然科学一等奖、国家自然科学二等奖等。

  获奖情况

 招生专业

生物学、统计学

   代表论文

1. Xixian Ma#, Wenjun Yang#, Yang Gao, Yuwen Pan, Yan Lu, Hao Chen, Dongsheng Lu, Shuhua Xu*. Genetic origins and sex-biased admixture of the Huis. Molecular Biology and Evolution. 2021. Doi:10.1093/molbev/msab158.

2. Lan-Tao Gou, Yang Gao, Jun-Yan Kang, Xin Wang, Hao Chen, Min-Min Hua, Zheng Li, Dangsheng Li, Xiang-Dong Fu, Hui-Juan Shi*, Shuhua Xu* and Mo-Fang Liu*. Reply to Lack of evidence for a role of PIWIL1 variants in human male infertility. Cell. 2020. 184(8):1943-1944.

3. Hao Chen#, Yan Lu#, Dongsheng Lu & Shuhua Xu*. Y-LineageTracker: a high-throughput analysis framework for Y-chromosomal next-generation sequencing data. BMC Bioinformatics. 2021. 22:114.

4. Ziqing Pan and Shuhua Xu*. Population genomics of East Asian ethnic groups. Hereditas. 2020. 157:49.

5. Yang Gao#, Chao Zhang#, Liyun Yuan#, YunChao Ling, Xiaoji Wang, Chang Liu, Yuwen Pan, Xiaoxi Zhang, Xixian Ma, Yuchen Wang, Yan Lu, Kai Yuan, Wei Ye, Jiaqiang Qian, Huidan Chang, Ruifang Cao, Xiao Yang, Ling Ma, Yuanhu Ju, Long Dai, Yuanyuan Tang, The Han100K Initiative, Guoqing Zhang, Shuhua Xu*.  PGG.Han: The Han Chinese Genome Database and Analysis Platform. Nucleic Acids Research. 2020, 48(D1):D971-D976.

6. Chao Zhang#, Yang Gao#, Zhilin Ning#, Yan Lu#, Xiaoxi Zhang, Jiaojiao Liu, Bo Xie, Zhe Xue, Xiaoji Wang, Kai Yuan, Xueling Ge, Yuwen Pan, Chang Liu, Lei Tian, Yuchen Wang, Dongsheng Lu, Boon-Peng Hoh, Shuhua Xu*.  PGG.SNV: Understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations. Genome Biology. 2019, 20:215.

7. Lian Deng#, Chao Zhang#, Kai Yuan#, Yang Gao#, Yuwen Pan, Xueling Ge, Yaoxi He, Yuan Yuan, Yan Lu, Xiaoxi Zhang, Hao Chen, Haiyi Lou, Xiaoji Wang, Dongsheng Lu, Jiaojiao Liu, Lei Tian, Qidi Feng, Asifullah Khan, Yajun Yang, Zi-Bing Jin, Jian Yang, Fan Lu, Jia Qu, Longli Kang, Bing Su, Shuhua Xu*. Prioritizing natural selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders. National Science Review. 2019, 6(6):1201–1222.

8. Chao Zhang#, Yang Gao#, Jiaojiao Liu, Zhe Xue, Yan Lu, Lian Deng, Lei Tian, Qidi Feng, Shuhua Xu*.  PGG.Population: a database for understanding the genomic diversity and genetic ancestry of human populations. Nucleic Acids Research. 2018, 46:D984–D993.

9. Chao Zhang#, Yan Lu#, Qidi Feng#, Xiaoji Wang#, Haiyi Lou, Jiaojiao Liu, Zhilin Ning, Kai Yuan, Yuchen Wang, Ying Zhou, Lian Deng, Lijun Liu, Yajun Yang, Shilin Li, Lifeng Ma, Zhiying Zhang, Li Jin, Bing Su, Longli Kang, Shuhua Xu*. Differentiated demographic histories and local adaptations between Sherpas and Tibetans. Genome Biology. 2017, 18:115.

10. Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*. Genetic history of Xinjiang’s Uyghurs suggests Bronze Age multiple-way contacts in Eurasia. Molecular Biology and Evolution. 2017, 34:2572-2582.

11. Dongsheng Lu, Haiyi Lou, Kai Yuan, Xiaoji Wang, Yuchen Wang, Chao Zhang, Yan Lu, Xiong Yang, Lian Deng, Ying Zhou, Qidi Feng, Ya Hu, Qiliang Ding, Yajun Yang, Shilin Li, Li Jin, Yaqun Guan, Bing Su, Longli Kang, and Shuhua Xu*. Ancestral Origins and Genetic History of Tibetan Highlanders. American Journal of Human Genetics. 2016, 99:580-594.

12. Haiyi Lou, Yan Lu, Dongsheng Lu, Ruiqing Fu, Xiaoji Wang, Qidi Feng, Sijie Wu, Yajun Yang, Shilin Li, Longli Kang, Yaqun Guan, Boon-Peng Hoh, Yeun-Jun Chung, Li Jin, Bing Su, Shuhua Xu*. A 3.4-kb Copy-Number Deletion near EPAS1 Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence. American Journal of Human Genetics. 2015, 97(1):54-66.

13. Wenfei Jin, Sijia Wang, Haifeng Wang, Li Jin, Shuhua Xu*. Exploring Population Admixture Dynamics Using Empirical and Simulated Genome-Wide Distribution of Ancestral Chromosomal Segments. American Journal of Human Genetics. 2012, 91:849-862.

14. Shuhua Xu*. Human Population Admixture in Asia. Genomics & Informatics. 2012, 10(2):133-144.

15. Shuhua Xu*, Sanchit Guputa and Li Jin*. PEAS V1.0: A Package for Elementary Analysis of SNP Data. Molecular Ecology Resources. 2010, 10:1085-1088.

16. The HUGO Pan-Asian SNP Consortium (Li Jin*, Edison T. Liu*, Mark Seielstad*, Shuhua Xu*; 93 authors from 10 countries). Mapping Genetic Diversity in Asia. Science. 2009, 326:1541-1545.