工作经历
2009年获加拿大多伦多大学理学博士学位。然后在美国哈佛大学医学院贝斯以色列女执事医学中心(HMS/BIDMC)和美国德克萨斯大学西南医学中心(UTSW)从事博士后研究,2014年任美国德克萨斯大学西南医学中心讲师。 2017年至今任复旦大学生命科学院教授,遗传工程国家重点实验室PI。国家重点研发计划‘发育编程及其代谢调节’重点专项项目首席科学家,生理学和生物物理学系系主任,中国生物物理学会副秘书长。主要研究大脑和周边器官包括脂肪,肌肉和肝脏等在调节能量代谢/糖脂代谢中的重要作用。
研究方向
采用组织特异性过表达或者敲除动物模型为研究对象, 结合生理学和神经学来研究肥胖,糖尿病及其相关代谢综合症的病理机制。着眼于将基础研究中的新发现转化为新颖的药理和临床干预疾病的研究。已经在Cell, Cell Metabolism, Nature Neuroscience, Neuron (封面和推荐文章)等杂志发表50多篇文章。
获奖情况
1. American Diabetes Association Young Investigator Travel Grant Award, 2014
2. Dr. Anna Shawyer Scholarships – University of Toronto, 2007.
3. Government of Ontario/ Dr. Arnie Aberman Graduate Scholarships in Science and Technology – University of Toronto, 2006.
招生专业
神经生物学、遗传学、生物与医药
代表论文
1. Wang R*, Guo S, Tian H, Huang Y, Yang Q, Zhao K, Kuo CH, Hong S, Chen P*, Liu T*. Hypoxic training in obese mice improves metabolic disorder. Front Endocrinol, 8;10:527, 2019.
2. Kong X*, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T*, Rosen ED*. Brown adipose tissue controls skeletal muscle function via the secretion of myostatin. Cell Metabolism, 28(4):631-643, 2018
3. Yong G, Yao T, Deng Z, Sohn JW, Jia S, Huang Y, Kong X,Yu KJ, Wang RT, Chen H, Guo H, Yan J, Cunningham KA, Chang Y*, Liu T* and Williams KW*. TrpC5 mediates acute leptin and serotonin effects via Pomc neurons. Cell Rep 17;18(3):583-592, 2017.
4. Yao T, Deng Z, Yong G, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu K, Findley BG, Berglund ED, Wang R, Guo H, Chen H, Li X, Kaufman RJ, Yan J*, Liu T* and Williams KW*. Ire1α in Pomc neurons is required for thermogenesis and glycemia. Diabetes 66(3):663-673, 2017.
5. Berglund ED*, Liu T*, Kong X*, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, and Elmquist JK. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nature Neuroscience, 17(7):911-3. 2014.
6. Liu T*, Kong D*, Shah BP*, Ye C*, Koda S, Saunders A, Ding , Yang Z, Sabatini BL and Lowell BB. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron 73(3), 511-22, 2012.
a. Featured by Neuron as Cover: Neuron 73(3): 2012.
b. Featured Article by Neuron: Neuron 73(3): 2012.
c. Featured by Cell Metabolism with a preview: Transmitter Time: Synaptic plasticity and Metabolic Memory in the Hypothalamus. Cell Metabolism 15: 275-27 (2012).