田梅教授，博士生导师

 

复旦大学人类表型组研究院  执行院长

复旦大学全球合作促进中心  主任

复旦大学附属华山医院核医学/PET中心  学科带头人

教育部“长江学者”特聘教授 （影像医学与核医学）

国家杰出青年科学基金获得者 （核医学与分子影像）

科技部“重点领域创新团队”负责人 （核医学与分子影像）

世界分子影像学会主席


Email: tianmei@fudan.edu.cn

 工作经历

复旦大学特聘教授、影像医学与核医学博士生导师。 

长期从事影像医学与核医学、分子影像的临床、教学和科研工作，先后在国内外获得临床医学学士、影像医学硕士、内科学博士。在日本、美国留学和工作十多年，曾担任日本学术振兴会特别研究员、哈佛大学医学院Dana-Farber Cancer Institute/Brigham and Women医院放射科临床研究员、美国MD Anderson癌症中心影像诊断部助理教授、浙江大学医学院附属第二医院核医学/PET中心教授、博士生导师。2020年当选世界分子影像学会（WMIS）主席，目前担任中国认知科学学会副理事长、上海市欧美同学会副会长、上海市政协委员。 

长期应邀担任“美国核医学与分子影像学会”会刊《Journal of Nuclear Medicine》副主编；“欧洲核医学会”会刊《European Journal of Nuclear Medicine and Molecular Imaging》副主编；“日本核医学会”会刊《Annals of Nuclear Medicine》副主编；“英国核医学会”会刊《Nuclear Medicine Communications》编辑委员；“世界分子影像学会”会刊《Molecular Imaging and Biology》亚洲地区负责人；英国皇家化学会《Sensors & Diagnostics》副主编；中国科协和美国科学促进会《Research》副主编；中国工程院院刊《Frontiers of Medicine》(中文名：医学前沿)、人民卫生出版社《Global Health Journal》（中文名：全球健康杂志）、《The Innovation Medicine》等刊编辑委员；英国柳叶刀《Lancet》编辑顾问。 

目前主持国家自然科学基金“核医学精准诊疗”重大项目、A3前瞻国际重点项目等，发表SCI英文论文200余篇，主编全国统编教材《核医学》2部、副主编3部，主编英文专著2部。

 研究方向

主要研究方向：针对人类重大疾病的诊治难题，通过构建核医学与分子影像新技术与新方法，提高疑难疾病的早期发现、早期诊断效率和准确性，科学合理设计临床诊断、治疗方案，精准制定临床疗效评估及预后监测体系。

研究内容涵盖：

•分子影像探针：研发并应用具有特异性分子识别能力的影像示踪剂，用于精确标记疾病靶点。

•多模态影像融合：结合PET/CT和PET/MRI技术，提升影像的空间分辨率和功能信息整合能力。

•人工智能辅助：开发AI辅助影像分析工具，实现精准化和自动化诊断。

•基于表型组学、分子影像的精准诊断与新型治疗方法（包括干细胞、T细胞治疗、靶向治疗等）。

•多模态影像（PET/CT/MRI/光学等）介导的精准诊治疗一体化基础研究与临床应用。


招生专业

医学影像学、人类表型组学、生物化学与分子生物学

 获奖情况

曾获教育部科技进步一等奖、中国产学研合作创新一等奖、日内瓦国际发明展金奖、中国青年科技奖、中国青年女科学家奖、中国青年五四奖章、世界分子影像（WMIS）Fellow等奖项。

国内外专著教材

1.主编：全国高等学校五年制本科临床医学专业第十轮规划教材《核医学》（第十版），2024年出版，ISBN：9787117368490，人民卫生出版社。 

2.主编：全国高等学校八年制及“5+3”一体化临床医学专业国家卫生健康委员会规划教材《核医学》（第四版），2024年出版，ISBN：9787117348423，人民卫生出版社。 

3.主编：《Transpathology: Molecular Imaging-Based Pathology》，Mei Tian，2024年出版，ISBN：9780323952231，Elsevier出版社。 

4.主编：《Drug Delivery Applications of Noninvasive Imaging》，Chun Li & Mei Tian，2013年出版，ISBN：9780470633472，Wiley出版社。 

5.副主编：《人工智能医学影像伦理手册》，2023年出版，ISBN：9787542681614，上海三联书店。 

6.副主编：全国高等学校五年制本科临床医学专业第九轮规划教材《核医学》（第九版），2018年出版，ISBN：9787117266710，人民卫生出版社。 

7.副主编：国家卫生和计划生育委员会“十三五”临床医学专业英文版规划教材《医学影像学》，2017年出版，人民卫生出版社。 

8.参编：全国高等学校放射诊断与治疗学专业国家卫生和计划生育委员会研究生规划教材《分子影像学》，2017年出版，人民卫生出版社。 

9.参编：《Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy》，2016年出版，ISBN：9784431558927, Springer出版社。 

10.参编：全国高等学校医学研究生卫生部规划教材《核医学》第二版，2014年出版, ISBN：9787117189491，人民卫生出版社。 

11.参编：全国高等学校八年制及七年制临床医学等专业用规划教材《核医学》第二版，2010年出版，ISBN：978-7-117-12991-6/R.2992，人民卫生出版社。

 代表论文

  1. Dai J, Xu H, Chen T, Huang T*, Liang W, Zhang R, Xu G, Zhang Z, Xue L, Gao Y, Zheng M, Feng G, Zhang Z, Tang J, Zhan J, Zhou Y*, Li Y*, Li Y*, Tian M*. Artificial intelligence for medicine 2025: Navigating the endless frontier. The Innovation Medicine. 2025 Feb 21;3:100120.

  2. Cen P, Cui C, Huang J, Chen H, Wu F, Niu J, Zhong Y, Jin C, Zhu WH, Zhang H*, Tian M*. Cellular senescence imaging and senolysis monitoring in cancer therapy based on a β-galactosidase-activated aggregation-induced emission luminogen. Acta biomaterialia. 2024 Apr 15;179:340-353.

  3. Wang J, Xue L, Jiang J, Liu F, Wu P, Lu J, Zhang H, Bao W, Xu Q, Ju Z, Chen L, Jiao F, Lin H, Ge J*, Zuo C*, Tian M*. Diagnostic performance of artificial intelligence-assisted PET imaging for Parkinson's disease: a systematic review and meta-analysis. NPJ digital medicine. 2024 Jan 22;7(1):17.

  4. Hong J, Lu J, Liu F, Wang M, Li X, Clement C, Lopes L, Brendel M, Rominger A, Yen TC, Guan Y, Tian M, Wang J*, Zuo C*, Shi K; Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI). Uncovering distinct progression patterns of tau deposition in progressive supranuclear palsy using [18F]Florzolotau PET imaging and subtype/stage inference algorithm. EBioMedicine. 2023 Nov;97:104835.

  5. Zhao S, Wang J, Jin C, Zhang X, Xue C, Zhou R, Zhong Y, Liu Y, He X, Zhou Y, Xu C, Zhang L, Qian W, Zhang H, Zhang X*, Tian M*. Stacking Ensemble Learning-Based [18F]FDG PET Radiomics for Outcome Prediction in Diffuse Large B-Cell Lymphoma. J Nucl Med. 2023 Oct;64(10):1603-1609.

  6. Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M*, Liu X*. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances. 2022 Apr 15;8(15):eabk2376.

  7. Jin C, Luo X, Li X, Zhou R, Zhong Y, Xu Z, Cui C, Xing X, Zhang H*, Tian M*. Positron emission tomography molecular imaging-based cancer phenotyping. Cancer. 2022 Jul 15;128(14):2704-2716. doi: 10.1002/cncr.34228. Epub 2022 Apr 13.

  8. Yu F, Li M, Wang Q, Wang J, Wu S, Zhou R, Jiang H, Li X, Zhou Y, Yang X, He X, Cheng Y, Ren X*, Zhang H*, Tian M*. Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model. Eur J Nucl Med Mol Imaging. 2022 Mar 19. doi: 10.1007/s00259-022-05764-2. Online ahead of print.

  9. Zhou R, Qin S, Cho W C. S., Zhou J, Jin C, Zhong Y, Wang J, Zhang X, Xu Z, Tian M*, Chan W.C*, Zhang H*. Microbiota-microglia connections in age-related cognition decline. Aging Cell. 2022 Mar 29;e13599.

  10. Zhang T, Li Y, Zhao S, Xu Y, Zhang X, Wu S, Dou X, Yu C, Feng J, Ding Y, Zhu J, Chen Z, Zhang H*, Tian M*. High-resolution pediatric age-specific 18F-FDG PET template: A pilot study in epileptogenic focus localization. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1560-1573.

  11. Zhang K, Mizuma H, Nakatani Y, Kanayama Y, Takahashi K, Matsumoto Y, Wada Y, Onoe K, Hayashinaka E, Wu Y, Zhang X, Tian M*, Zhang H*, Watanabe Y*. Neural correlates of beneficial effects of young plasma treatment in aged mice: PET-SPM analyses and neuro-behavioural/molecular biological studies. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1456-1469.

  12. Huang H, Sun Z, Yang H, Yang X, Wu F, Sun Y, Li C*, Tian M*, Zhang H*, Wang Q*. Precise Examination of Peripheral Vascular Disease for Diabetics with a Novel Multiplexed NIR-II Fluorescence Imaging Technology. Nanotoday. 43(2022):101378.

  13. Ouyang J, Sun L, Pan J, Zeng Z, Zeng C, Zeng F*, Tian M*, Wu S*. A Targeted Nanosystem for Detection of Inflammatory Diseases via Fluorescent/Optoacoustic Imaging and Therapy via Modulating Nrf2/NF-kB Pathways. Small. 2021 Oct;17(42):e2102598.

  14. Li Y, Feng J, Zhang T, Shi K, Ding Y, Zhang X, Jin C, Pan J, Xue L, Liao Y, Wang X, Zhuo C, Zhang H*, Tian M*. Brain metabolic characteristics distinguishing typical and atypical benign epilepsy with centro-temporal spikes. Eur Radiol. 2021 Dec;31(12):9335-9345.

  15. Sun H, Zhong Y, Zhu X, Liao H, Lee J, Chen Y, Ma L, Ren J, Zhao M, Tu M, Li F, Zhang H, Tian M*, Ling D*. A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's disease. ACS Nano. 2021 Mar 23;15(3):5263-5275.

  16. Li X, Zhang K, He X, Zhou J, Jin C, Shen L, Gao Y, Tian M*, Zhang H*. Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder. Neuroscience Bulletin. 2021 Jul; 37(7):1051-1071.

  17. Zhang K*, Mizuma H, Zhang X, Takahashi K, Jin C, Song F, Gao Y, Kanayama Y, Wu Y, Li Y, Ma L, Tian M*, Zhang H*, Watanabe Y*. PET imaging of neural activity, β-amyloid, and tau in normal brain aging. Eur J Nucl Med Mol Imaging. 2021 Nov;48(12):3859-3871.

  18. Wang C, Sun W, Zhang J, Zhang J, Guo Q, Zhou X, Fan D, Liu H, Qi M, Gao X, Xu H, Gao Z, Tian M, Zhang H, Wang J, Wei Z, Long N, Mao Y*, Li C*. An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy. Nat Biomed Eng. 2021 Mar;5(3):278-289.

  19. Gao Y, Wu S, Pan J, Zhang K, Li X, Xu Y, Jin C, He X, Shi J, Ma L, Wu F, Yao Y, Wang P , He Q, Lan F*, Zhang H*, Tian M*. CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes. Eur J Nucl Med Mol Imaging. 2021 Mar; 48(3):708-720

  20. Tian M*, He X, Jin C, He X, Wu S, Zhou R, Zhang X, Zhang K, Gu W, Wang J, Zhang H*. Transpathology: molecular imaging based pathology. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2338-2350.

  21. Zhang Q, Liao Y, Wang X, Zhang T, Feng J, Deng J, Shi K, Chen L, Feng L, Ma M, Xue L, Hou H, Dou X, Yu C, Ren L, Ding Y, Chen Y, Wu S, Chen Z, Zhang H*, Zhuo C*, Tian M*. A Deep Learning Framework for 18F-FDG PET Imaging Diagnosis in Pediatric Patients with Temporal Lobe Epilepsy. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2476-2485.

  22. Zhang K, Sun Y, Wu S, Zhou M, Zhang X, Zhou R, Zhang T, Gao Y, Chen T, Chen Y, Yao X, Watanabe Y*, Tian M*, Zhang H*. Systematic imaging in medicine: a comprehensive review. Eur J Nucl Med Mol Imaging. 2021 Jun; 48(6):1736-1758.

  23. Cai X, Zhang K, Xie X, Zhu X, Feng J, Jin Z, Zhang H, Tian M*, Chen H*. Self-assembly hollow manganese Prterm sussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline. Biomaterials, 2020 Feb;231:119678

  24. Dong S, Zhao J, Zhang M, Shi Z, Deng J, Shi Y, Tian M, Zhuo C*. DeU-Net: Deformable U-Net for 3D Cardiac MRI Video Segmentation. MICCAI 2020: Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 pp 98-107.

  25. Du R, Zhu X, Wu , Zhang X, He Y, Zhang K, He X, Wang X, Sun Y, Wang Q, Zhang H*, Tian M*. PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2019 Oct;46(11):2392-2397.

  26. He X*, Ji J, Tian M, Esteva FJ, Hortobagyi GN, Yeung SJ*. Long-Term Survival Analysis of Adjuvant Chemotherapy with or without Trastuzumab in Patients with T1, Node-Negative HER2-Positive Breast Cancer. Clin Can Res. 2019 Dec 15; 25(24): 7388-7395.

  27. Zhang K, Tu M, Gao W, Cai X*, Song F, Chen Z, Zhang Q, Wang J, Jin C, Shi J, Yang X, Zhu Y, Gu W, Hu B, Zheng Y*, Zhang H*, Tian M*. Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis. Nano Lett. 2019 May 8;19(5):2812-2823.

  28. Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL*, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG*. MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2806-2811.

  29. Chen Q, Du Y, Zhang K, Liang Z, Li J, Yu H, Ren R, Feng J, Jin Z, Li F, Sun J, Zhou M, He Q, Sun X, Zhang H, Tian M*, Ling D*. Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease. ACS Nano. 2018 Feb 27;12(2):1321-1338.

  30. Ding Y, Zhu Y, Jiang B, Zhou Y, Jin B, Hou H, Wu S, Zhu J, Wang ZI, Wong CH, Ding M, Zhang H, Wang S, Tian M*. 18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2018 Jul;45(9):1567-1572.

  31. 31.Zhu Y, Feng J, Ji J, Hou H, Chen L, Wu S, Liu Q, Yao Q, Du P, Zhang K, Chen Q, Chen Z, Zhang H, Tian M*. Alteration of monoamine receptor activity and glucose metabolism in  pediatric patients with anticonvulsant-induced cognitive impairment. J Nucl Med. 2017 Sep;58(9):1490-1497.

  32. Zhu Y, Feng J, Wu S, Hou H, Ji J, Zhang K, Chen Q, Chen L, Cheng H, Gao L, Chen Z, Zhang H, Tian M*. Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy. J Nucl Med. 2017 Aug; 58(8):1293-1299.

  33. Chen Q, Zhang Y, Hou H, Du F, Wu S, Chen L, Shen Y, Chao F, Chung JK, Zhang H, Tian M*. Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging. Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1033-1041.

  34. Wu S, Zhu Y, Liu H, Tang L, Du R, Shen Y, Feng J, Zhang K, Xu C, Zhang S, Chen Y, Song F, Zhu Y, Gu W, Liang P, Carrio I, Zhang H, Tian M*. In Vivo Dynamic Metabolic Changes After Transplantation of Induced Pluripotent Stem Cells for Ischemic Injury. J Nucl Med. 2016 Dec; 57(12):2012-2015.

  35. Zhu Y, Xu K, Xu C, Zhang J, Ji J, Zheng X, Zhang H, Tian M*. PET Mapping for Brain–Computer Interface Stimulation of the Ventroposterior Medial Nucleus of the Thalamus in Rats with Implanted Electrodes. J Nucl Med. 2016 Jul; 57(7):1141-1145.

  36. Zhu Y, Du R, Zhu Y, Shen Y, Zhang K, Chen Y, Song F, Wu S, Zhang H, Tian M*. PET mapping of neurofunctional changes in a posttraumatic stress disorder model. J Nucl Med. 2016 Sep; 57(9):1474-1477.

  37. Zhang H, Song F, Xu C, Liu H, Wang Z, Li J, Wu S, Shen Y, Chen Y, Zhu Y, Du R, Tian M*. Spatiotemporal PET Imaging of Dynamic Metabolic Changes After Therapeutic Approaches of Induced Pluripotent Stem Cells, Neuronal Stem Cells, and a Chinese Patent Medicine in Stroke. J Nucl Med. 2015 Nov; 56(11):1774-1779.