工作经历
2022.08-至今，复旦大学人类表型组研究院，青年研究员
2020.11-2022.07， 中国科学院脑科学与智能技术卓越创新中心， 生物信息工程师
2019.09-2020.09， 斯坦福大学医学院， 博士后
2015.10-2019.06， 巴黎索邦西岱大学（巴黎第五大学）， 遗传学， 博士
研究方向
使用多组学手段研究心脏瓣膜病的遗传学机制
研究复杂环境对心血管疾病的影响
复杂疾病的多基因风险评估
招生专业
遗传学、生物信息学
代表论文
1、Chen Meng, Haibi Su, Meiling Shu, Feng Shen, Yijie Lu, Shishi Wu, Zhenghua Su, Mengyao Yu#, Di Yang#. The functional role of m6A demethylase ALKBH5 in cardiomyocyte hypertrophy. Cell Death Dis. 2024;15(9):683. (IF=8.1, JCR Q1)
2、 Shuo Wang*, Meng Liu*, Yan Li*, Xinyu Zhang, Mengting Sun, Zian Wang, Ruokun Li, Qirong Li, Qing Li, Yili He, Xumei Hu, Longyu Sun, Fuhua Yan, Mengyao Yu#, Weiping Ding#, Chengyan Wang#. Recent Advances in Data-driven Fusion of Multi-modal Imaging and Genomics for Precision Medicine. Information Fusion. 2024: 102738. (IF=14.7, JCR Q1)
3、 Mengyao Yu*#, Nabila Bouatia-Naji#. "Insights into the Inherited Basis of Valvular Heart Disease." Curr Cardiol Rep. 2024: 1-12. (IF=3.1, JCR Q1)
4、 Mengyao Yu*, Andrew R. Harper*, Matthew Aguirre, et al., "Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy." Circ Genom Precis Med. 2023;16(3):207-215. (IF=7.5, JCR Q1)（精选论文）
5、 Mengyao Yu, Matthew Aguirre, Meiwen Jia, et al., "Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes." Circ Genom Precis Med. 2023;16(3):258-266. (IF=7.5, JCR Q1)
6、Mengyao Yu, Catherine Tcheandjieu, Adrien Georges, et.al., Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease. JCI Insight. 2022;7(3):e146580. (IF=9.4, JCR Q1)（AHA协会推荐论文）
7、Carolina Roselli, Mengyao Yu, Victor Nauffal, et.al., Genome-wide Association Study reveals Novel Genetic Loci and Polygenic Risk Score for Mitral Valve Prolapse. Eur Heart J. 2022;43(17):1668-1680. (IF=35.86, JCR Q1)(同行专家在欧洲心脏病学会杂志（ESC）上发表评述)
8、Mengyao Yu, Sergiy Kyryachenko, Stephanie Debette, et.al., Genome-wide association meta-analysis supports genes involved in valve and cardiac development to associate with mitral valve prolapse. Circ Genom Precis Med. 2021;14(5):e003148. (IF=7.5, JCR Q1)
9、 Sergiy Kyryachenko*, Adrien Georges*, Mengyao Yu*, et.al., Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. Circ Res. 2021;128(5):e84-e101. (IF=17.3, JCR Q1)(精选论文)
10、 Hafid Ait-Oufella*, Mengyao Yu*, Adrien Georges, et. al., Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study. Int J Cardiol.2021;344:213-219. (IF=4.2, JCR Q2)
11、Catherine Tcheandjieu, Daniela Zanetti, Mengyao Yu, James Priest. Inherited extremes of aortic diameter confer risk for a specific class of congenital heart disease. Circ Genom Precis Med. 2020;13(6):e003170. (IF=7.5, JCR Q1)
12、 Mengyao Yu, Adrien Georges, Nathan R. Tucker, et.al., Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. 2019;12(5):e002497. (IF=7.5, JCR Q1)(封面论文)
13、Katelynn Toomer*, Mengyao Yu*, Diana Fulmer*, et.al., Primary cilia defects causing mitral valve prolapse. Sci Transl Med.2019;11(493):eaax0290.(IF=21.1, JCR Q1)（同行专家在Nature reviews cardiology发表评述，高亮论文）
