复旦大学特聘教授、复旦大学人类表型组研究院副院长、复旦大学时空组学整合研究中心主任、复旦大学附属肿瘤医院双聘教授、英国爱丁堡大学生殖健康中心荣誉研究员。曾获上海市领军人才、上海浦东“明珠计划”领军人才，CRUK CDF英国癌症研究职业发展奖、爱丁堡大学学院早期成就奖、前列腺癌症基金会（PCF）挑战奖及美国癌症研究协会（AACR）在训学者奖等奖项，2024-25连续两年被爱思唯尔评为中国高被引学者。

长期致力于肿瘤免疫、巨噬细胞及空间组学研究。发现并命名了转移相关巨噬细胞，开创了免疫细胞在肿瘤转移中作用的新领域，在揭示巨噬细胞促进癌症转移及耐药机制方面取得了系列开创性成果。目前研究聚焦于单细胞时空组学和人工智能技术的结合与应用。主持国际重大科研项目总经费超3,000万人民币，其中包括欧盟科学研究委员会（ERC）地平线2020项目、英国癌症研究（CRUK）CDF重大项目及国家自然科学基金和上海市级重大项目等。在 Nature、Cell、Nature Reviews Immunology、Journal of Experimental Medicine、Trends in Immunology 、Nature Computational Science等国际顶尖期刊发表多篇高水平学术论文，其中ESI高被引9篇，论文总引用超18,000次,参与编写国际学术专著2本。

目前担任《Journal of Leukocyte Biology》、《CytoJournal》、《Clinical and Experimental Metastasis》等期刊编委 ，受邀为 Nature、Cell、Science 等数十种国际权威刊物审稿，并担任十余个国际基金项目的评审专家。目前担任生命科学开放联盟秘书长、中国生物工程学会系统生物医学专委会副主任委员、上海生物信息学会理事时空组学专委会副主任委员、全国卫生产业企业管理协会精准医疗分会理事等社会职务。

研究方向

空间组学；肿瘤免疫；肿瘤微环境；生物信息学

获奖情况

2024年上海浦东明珠计划领军人才

2022年上海市领军人才

2015年爱丁堡大学学院早期成就奖

2014年英国癌症研究职业发展奖

2013年Movember-Prostate Cancer Foundation 挑战奖

2013年Dennis Shields纪念基金研究奖： 最佳博士后研究奖

2012年Susan G. Komen for the Cure 博士后奖

2012年美国癌症研究协会在训学者奖（103期）

2011年美国癌症研究协会在训学者奖（102期）

2007年Keystone炎-癌共性机制专题会议奖

代表论文

1. Yan Y, Gu T, Sun C, Zhang Y, Cui Y, Lin S, Zou Q, Du Y, Han C, Kang K, Li S, Zhao Y, Lin Z, Yuan Z, Qian BZ. Benchmarking alignment methods for spatial transcriptomics data. Nature Computational Science. 2026 Apr 3:1-8.

2.  Zhang Y, Yang C, Chen X, Wu L, Yuan Z, Zhang F, Qian BZ. Cancer therapy resistance from a spatial‐omics perspective. Clinical and Translational Medicine. 2025 Jul;15(7):e70396.

3. Yu J, QianBZ. Cellular stress and macrophage activation Seminars in Immunology, 2025; 78:101953. Doi: 10.1016/j.smim.2025.101953

4. Yang Y, Chen Y, Pei P, Fan Y, Wang S, Zhang H, Zhao D, Qian BZ, Zhang F. Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging. Nat Nanotechnol. 2023 Jun 22. doi: 10.1038/s41565-023-01422-2.

5. Li XF, Selli C, Zhou H, Cao J, Wu S, Ma RY, Lu Y, Zhang CB, Xun B, Lam AD, Pang XC, Fernando A, Zhang Z, Unciti-Broceta A, Carragher NO, Ramachandran P, Henderson NC, Sun LL, Hu HY, Li GB, Sawyers C, Qian BZ. Macrophages promote anti-androgen resistance of prostate cancer bone disease. J Exp Med. 2023 Apr 3;220(4):e20221007. doi: 10.1084/jem.20221007.

6. Ma RY; Black A; Qian BZ. Macrophage diversity in cancer revisited in the era of single-cell omics. Trends Immunol. 2022 Jul;43(7):546-563. DOI: 10.1016/j.it.2022.04.008

7. Ma RY, Zhang H, Li XF, Zhang CB, Selli C, Tagliavini G, Prost S, Sims AH, Hu HY, Ying T, Wang Z, Ye Z, Pollard JW, Qian BZ. Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth. J Exp Med. 2020, 217 (11): e20191820

8. Pang, X, Gong, K, Zhang, X, Wu, S, Cui, Y, and Qian BZ (2019). Osteopontin as a multifaceted driver of bone metastasis and drug resistance. Pharmacol. Res. 144, 235-244.

9. Graham N, Qian BZ. Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis. Int. J. Mol. Sci. 2018, 19(4), 1121; doi:10.3390/ijms19041121

10. Gómez-Cuadrado L, Tracey N, Ma R, Qian BZ, Brunton VG Mouse models of metastasis: progress and prospects. Disease Models and Mechanisms. 2017 Sep 1;10(9):1061-1074. doi: 10.1242/dmm.030403.

11. Qian BZ. Inflammation fires up cancer metastasis. Seminars in Cancer Biology. 2017 Aug 31. pii: S1044-579X(17)30210-9. doi: 10.1016/j.semcancer.2017.08.006

12. Qin W, Zheng Y, Qian BZ#, Zhao M# Prostate cancer stem cells and nanotechnology: a focus on Wnt signaling. Front. Pharmacol. 2017 Mar 28; 8: 153 (# co-corresponding author)

13. Hughes R*, Qian BZ* Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW and Lewis CE. Perivascular M2 macrophages Stimulate Tumor Relapse After Chemotherapy. Cancer Research. 2015 Sep 1;75(17):3479-91 (co-first author)

14. Qian BZ#, Zhang H, Li J, He AT, Yeo EJ, Soong DYH, Carragher N, Munro A, Chang A, Bresnick AR, Lang RA and Pollard JW# FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J Exp Med 2015 Aug 24; 212(9):1433-48. (# co-corresponding author)

15. Harney AS, Arwert EN, Entenberg D, Wang Y, Qian BZ, Pollard JW, Jones JG and Condeelis JS. Real-time imaging reveals local, transient vascular permeability and tumor cell intravasation by Tie2Hi macrophage-derived VEGFA. Cancer Discov 2015 Sep;5(9):932-43.

16. Kitamura T, Qian BZ, Soogn D, Cassetta L, Noy R, Sugano G, Kato Y, Li J and Pollard JW CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J Exp Med 2015 Jun 29;212(7):1043-59.

17. Kitamura T, Qian BZ and Pollard JW Immune cell promotion of metastasis. Nature Review Immunology 2015 Feb. 2: 73-86.

18. Qian BZ, Li J, Zhang H, Kitamura T, Campion LR, Kaiser EA, Zhang J, Snyder LA and Pollard JW. CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis. Nature. 475, 222-25 July 14, 2011.

19. Qian BZ, Pollard JW. Macrophage Diversity Enhances Tumor Progression and Metastasis. Cell. 141, 39-51 April 2, 2010

20. Qian BZ, Deng Y, Im JH, Muschel RJ, Zou Y, et al. 2009. A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth. PLoS ONE. 4(8): e6562.