田梅教授，执行院长

 

教授，执行院长

博士生导师

国家杰出青年科学基金获得者

世界分子影像学会主席


Email: tianmei@fudan.edu.cn



 工作经历

教育部“长江学者”特聘教授、国家杰出青年科学基金获得者、科技部“重点领域创新团队”负责人。

长期从事影像医学与核医学、分子影像的临床、教学和科研工作，先后在国内外获得临床医学学士、影像医学硕士、内科学博士。曾在哈佛大学医学院Dana-Farber Cancer Institute/Brigham and Women医院工作，担任美国MD Anderson癌症中心助理教授。特别是近20年来，针对人类重大疾病的诊治难题，通过构建分子影像新技术、新方法，提高疑难疾病的早期诊断效率和准确率。通过研发和利用特异性分子识别的影像示踪剂（分子影像探针）、PET/CT及PET/MRI多模式影像融合技术、以及人工智能（AI）辅助影像分析技术，显著提高癫痫、老年痴呆、恶性肿瘤等的精准诊治水平。目前主持国家自然科学基金委杰出青年基金项目、国际重点合作A3项目、基础科学中心项目课题，发表SCI英文论文100多篇，主编全国统编教材1部、副主编2部，主编英文专著1部。

当选世界分子影像学会(WMIS)主席、中国认知科学学会分子影像分会理事长。长期应邀担任“美国核医学与分子影像学会”会刊《Journal of Nuclear Medicine》副主编；“欧洲核医学会”会刊《European Journal of Nuclear Medicine and Molecular Imaging》副主编；“日本核医学会”会刊《Annals of Nuclear Medicine》副主编；“英国核医学会”会刊《Nuclear Medicine Communications》编辑委员；“世界分子影像学会”会刊《Molecular Imaging Biology》亚洲地区负责人；《Oncology》编辑委员; 中国工程院院刊《Frontiers of Medicine》编辑委员；中国科协和美国科学促进会《Research》Associate Editor；英国柳叶刀《Lancet》编辑顾问。

 研究方向

  1. 表型组学、表型影像学、分子影像学；

  2. 基于表型影像、分子影像的精准诊断与新型治疗方法（包括干细胞、T细胞治疗，靶向治疗等），多模式（PET / CT / MRI / 光学等）影像介导的精准诊治一体化基础研究与临床应用；

  3. 基于分子影像的人类重大疾病（神经与精神疾病、心梗、恶性肿瘤等）临床诊断与治疗方案设计、疗效精准评估与预后监测；

  4. 基于脑机融合、影像组学、大数据、人工智能等的新型分子影像的精准临床诊治。

招生专业

生物化学与分子生物学

 获奖情况

  1. 教育部科技进步一等奖

  2. 中国产学研合作创新一等奖

  3. 日内瓦国际发明展金奖

  4. 中国青年科技奖、中国青年女科学家奖

  5. 中国青年五四奖章、全国三八红旗手

  6. 世界分子影像（WMIS）Fellow

 代表论文

  1. Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M*, Liu X*. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances. 2022 Apr 15;8(15):eabk2376.

  2. Jin C, Luo X, Li X, Zhou R, Zhong Y, Xu Z, Cui C, Xing X, Zhang H*, Tian M*. Positron emission tomography molecular imaging-based cancer phenotyping. Cancer. 2022 Apr 13. doi: 10.1002/cncr.34228. Online ahead of print.

  3. Yu F, Li M, Wang Q, Wang J, Wu S, Zhou R, Jiang H, Li X, Zhou Y, Yang X, He X, Cheng Y, Ren X*, Zhang H*, Tian M*. Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model. Eur J Nucl Med Mol Imaging. 2022 Mar 19. doi: 10.1007/s00259-022-05764-2. Online ahead of print.

  4. Zhou R, Qin S, Cho W C. S., Zhou J, Jin C, Zhong Y, Wang J, Zhang X, Xu Z, Tian M*, Chan W.C*, Zhang H*. Microbiota-microglia connections in age-related cognition decline. Aging Cell. 2022 Mar 29;e13599.

  5. Zhang T, Li Y, Zhao S, Xu Y, Zhang X, Wu S, Dou X, Yu C, Feng J, Ding Y, Zhu J, Chen Z, Zhang H*, Tian M*. High-resolution pediatric age-specific 18F-FDG PET template: A pilot study in epileptogenic focus localization. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1560-1573.

  6. Zhang K, Mizuma H, Nakatani Y, Kanayama Y, Takahashi K, Matsumoto Y, Wada Y, Onoe K, Hayashinaka E, Wu Y, Zhang X, Tian M*, Zhang H*, Watanabe Y*. Neural correlates of beneficial effects of young plasma treatment in aged mice: PET-SPM analyses and neuro-behavioural/molecular biological studies. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1456-1469.

  7. Qin X, Jiang H, Liu Y, Zhang H*, Tian M*. Radionuclide Imaging of Apoptosis for Clinical Application. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1345-1359.

  8. Zhang X, Chen L, Jiang H, He X, Feng L, Ni M, Ma M, Wang J, Zhang T, Wu S, Zhou R, Jin C, Zhang K, Qian W, Chen Z, Zhuo C, Zhang H*, Tian M*. A novel analytic approach for outcome prediction in diffuse large B-cell lymphoma by [18 F]FDG PET/CT. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1298-1310.

  9. Liu Y, Jiang H, Qin X, Tian M*, Zhang H*. PET imaging of reactive astrocytes in neurological disorders. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1275-1287

  10. Tian M*, Civelek AC*, Carrio I, Watanabe Y, Kang KW, Murakami K, Garibotto V, Prior JO, Barthel H, Zhou R, Hou HF, Dou XF, Jin CT, Zuo CT, Zhang H*. International consensus on the use of tau PET imaging agent F-18-flortaucipir in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2022 Feb;49(3):895-904

  11. Li Y, Zhang T, Feng J, Qian S, Wu S, Zhou R, Wang J, Sa G, Wang X, Li L, Chen F, Yang H, Zhang H*, Tian M*. Processing Speed Dysfunction is Associated with Functional Corticostriatal Circuit Alterations in Childhood Epilepsy with Centrotemporal Spikes: A PET and fMRI Study. Eur J Nucl Med Mol Imaging. 2022 Feb 24. doi: 10.1007/s00259-022-05740-w. Online ahead of print.

  12. Huang H, Sun Z, Yang H, Yang X, Wu F, Sun Y, Li C*, Tian M*, Zhang H*, Wang Q*. Precise Examination of Peripheral Vascular Disease for Diabetics with a Novel Multiplexed NIR-II Fluorescence Imaging Technology. Nanotoday. 43(2022):101378.

  13. Ouyang J, Sun L, Pan J, Zeng Z, Zeng C, Zeng F*, Tian M*, Wu S*. A Targeted Nanosystem for Detection of Inflammatory Diseases via Fluorescent/Optoacoustic Imaging and Therapy via Modulating Nrf2/NF-kB Pathways. Small. 2021 Oct;17(42):e2102598.

  14. Tian M*, Watanabe Y, Kang KW, Murakami K, Chiti A, Carrio I, Civelek A.C, Feng J, Zhu Y, Zhou R, Wu S, Zhu J, Ding Y, Zhang K, Zhang H*. International consensus on the use of [18F]‑FDG PET/CT in pediatric patients affected by epilepsy. Eur J Nucl Med Mol Imaging. 2021 Nov;48(12):3827-3834.

  15. Jin C, Luo X, Qian S, Zhang K, Gao Y, Zhou R, Cen P, Xu Z, Zhang H*, Tian M*. Positron emission tomography in the COVID-19 pandemic era. Eur J Nucl Med Mol Imaging, 2021, 48(12):3903-3917.

  16. Li Y, Feng J, Zhang T, Shi K, Ding Y, Zhang X, Jin C, Pan J, Xue L, Liao Y, Wang X, Zhuo C, Zhang H*, Tian M*. Brain metabolic characteristics distinguishing typical and atypical benign epilepsy with centro-temporal spikes. Eur Radiol. 2021 Dec;31(12):9335-9345.

  17. Sun H, Zhong Y, Zhu X, Liao H, Lee J, Chen Y, Ma L, Ren J, Zhao M, Tu M, Li F, Zhang H, Tian M*, Ling D*. A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's disease. ACS Nano. 2021 Mar 23;15(3):5263-5275.

  18. Li X, Zhang K, He X, Zhou J, Jin C, Shen L, Gao Y, Tian M*, Zhang H*. Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder. Neuroscience Bulletin. 2021 Jul; 37(7):1051-1071.

  19. Zhang K*, Mizuma H, Zhang X, Takahashi K, Jin C, Song F, Gao Y, Kanayama Y, Wu Y, Li Y, Ma L, Tian M*, Zhang H*, Watanabe Y*. PET imaging of neural activity, β-amyloid, and tau in normal brain aging. Eur J Nucl Med Mol Imaging. 2021 Nov;48(12):3859-3871.

  20. Wang C, Sun W, Zhang J, Zhang J, Guo Q, Zhou X, Fan D, Liu H, Qi M, Gao X, Xu H, Gao Z, Tian M, Zhang H, Wang J, Wei Z, Long N, Mao Y*, Li C*. An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy. Nat Biomed Eng. 2021 Mar;5(3):278-289.

  21. Gao Y, Wu S, Pan J, Zhang K, Li X, Xu Y, Jin C, He X, Shi J, Ma L, Wu F, Yao Y, Wang P , He Q, Lan F*, Zhang H*, Tian M*. CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes. Eur J Nucl Med Mol Imaging. 2021 Mar; 48(3):708-720

  22. Tian M*, He X, Jin C, He X, Wu S, Zhou R, Zhang X, Zhang K, Gu W, Wang J, Zhang H*. Transpathology: molecular imaging based pathology. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2338-2350.

  23. Zhang Q, Liao Y, Wang X, Zhang T, Feng J, Deng J, Shi K, Chen L, Feng L, Ma M, Xue L, Hou H, Dou X, Yu C, Ren L, Ding Y, Chen Y, Wu S, Chen Z, Zhang H*, Zhuo C*, Tian M*. A Deep Learning Framework for 18F-FDG PET Imaging Diagnosis in Pediatric Patients with Temporal Lobe Epilepsy. Eur J Nucl Med Mol Imaging. 2021 Jul;48(8):2476-2485.

  24. Zhang K, Sun Y, Wu S, Zhou M, Zhang X, Zhou R, Zhang T, Gao Y, Chen T, Chen Y, Yao X, Watanabe Y*, Tian M*, Zhang H*. Systematic imaging in medicine: a comprehensive review. Eur J Nucl Med Mol Imaging. 2021 Jun; 48(6):1736-1758.

  25. Cai X, Zhang K, Xie X, Zhu X, Feng J, Jin Z, Zhang H, Tian M*, Chen H*. Self-assembly hollow manganese Prterm sussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline. Biomaterials, 2020 Feb;231:119678

  26. Dong S, Zhao J, Zhang M, Shi Z, Deng J, Shi Y, Tian M, Zhuo C*. DeU-Net: Deformable U-Net for 3D Cardiac MRI Video Segmentation. MICCAI 2020: Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 pp 98-107.

  27. Du R, Zhu X, Wu , Zhang X, He Y, Zhang K, He X, Wang X, Sun Y, Wang Q, Zhang H*, Tian M*. PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2019 Oct;46(11):2392-2397.

  28. He X*, Ji J, Tian M, Esteva FJ, Hortobagyi GN, Yeung SJ*. Long-Term Survival Analysis of Adjuvant Chemotherapy with or without Trastuzumab in Patients with T1, Node-Negative HER2-Positive Breast Cancer. Clin Can Res. 2019 Dec 15; 25(24): 7388-7395.

  29. Zhang K, Tu M, Gao W, Cai X*, Song F, Chen Z, Zhang Q, Wang J, Jin C, Shi J, Yang X, Zhu Y, Gu W, Hu B, Zheng Y*, Zhang H*, Tian M*. Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis. Nano Lett. 2019 May 8;19(5):2812-2823.

  30. Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL*, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG*. MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2806-2811.

  31. Chen Q, Du Y, Zhang K, Liang Z, Li J, Yu H, Ren R, Feng J, Jin Z, Li F, Sun J, Zhou M, He Q, Sun X, Zhang H, Tian M*, Ling D*. Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease. ACS Nano. 2018 Feb 27;12(2):1321-1338.

  32. Ding Y, Zhu Y, Jiang B, Zhou Y, Jin B, Hou H, Wu S, Zhu J, Wang ZI, Wong CH, Ding M, Zhang H, Wang S, Tian M*. 18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2018 Jul;45(9):1567-1572.

  33. Zhu Y, Feng J, Ji J, Hou H, Chen L, Wu S, Liu Q, Yao Q, Du P, Zhang K, Chen Q, Chen Z, Zhang H, Tian M*. Alteration of monoamine receptor activity and glucose metabolism in  pediatric patients with anticonvulsant-induced cognitive impairment. J Nucl Med. 2017 Sep;58(9):1490-1497.

  34. Zhu Y, Feng J, Wu S, Hou H, Ji J, Zhang K, Chen Q, Chen L, Cheng H, Gao L, Chen Z, Zhang H, Tian M*. Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy. J Nucl Med. 2017 Aug; 58(8):1293-1299.

  35. Chen Q, Zhang Y, Hou H, Du F, Wu S, Chen L, Shen Y, Chao F, Chung JK, Zhang H, Tian M*. Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging. Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1033-1041.

  36. Wu S, Zhu Y, Liu H, Tang L, Du R, Shen Y, Feng J, Zhang K, Xu C, Zhang S, Chen Y, Song F, Zhu Y, Gu W, Liang P, Carrio I, Zhang H, Tian M*. In Vivo Dynamic Metabolic Changes After Transplantation of Induced Pluripotent Stem Cells for Ischemic Injury. J Nucl Med. 2016 Dec; 57(12):2012-2015.

  37. Zhu Y, Xu K, Xu C, Zhang J, Ji J, Zheng X, Zhang H, Tian M*. PET Mapping for Brain–Computer Interface Stimulation of the Ventroposterior Medial Nucleus of the Thalamus in Rats with Implanted Electrodes. J Nucl Med. 2016 Jul; 57(7):1141-1145.

  38. Zhu Y, Du R, Zhu Y, Shen Y, Zhang K, Chen Y, Song F, Wu S, Zhang H, Tian M*. PET mapping of neurofunctional changes in a posttraumatic stress disorder model. J Nucl Med. 2016 Sep; 57(9):1474-1477.

  39. Zhang H, Song F, Xu C, Liu H, Wang Z, Li J, Wu S, Shen Y, Chen Y, Zhu Y, Du R, Tian M*. Spatiotemporal PET Imaging of Dynamic Metabolic Changes After Therapeutic Approaches of Induced Pluripotent Stem Cells, Neuronal Stem Cells, and a Chinese Patent Medicine in Stroke. J Nucl Med. 2015 Nov; 56(11):1774-1779.


  国内外专著教材

  1. 主编：高等学校八年制及“5+3”一体化临床医学专业国家卫生健康委员会规划教材《核医学》（第四版）

  2. 主编：《Drug Delivery Applications of Noninvasive Imaging》，Chun Li & Mei Tian， ISBN 978-0-470-63347-2，2013年10月出版，美国Wiley出版社。

  3. 副主编：全国高等学校五年制本科临床医学专业第九轮规划教材《核医学》（第九版），2018年出版，人民卫生出版社。

  4. 副主编：国家卫生和计划生育委员会“十三五”临床医学专业英文版规划教材《医学影像学》，2017年出版，人民卫生出版社。

  5. 参编：全国高等学校放射诊断与治疗学专业国家卫生和计划生育委员会研究生规划教材《分子影像学》，2017年出版，人民卫生出版社。

  6. 参编：《Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy》，2016年出版，ISBN:978-4-431-55892-7, Springer出版社。

  7. 参编：全国高等学校医学研究生卫生部规划教材《核医学》第二版，2014年7月出版, ISBN：978-7-117-18949-1，人民卫生出版社。

  8. 参编：全国高等学校八年制及七年制临床医学等专业用规划教材《核医学》第二版，2010年8月出版，ISBN：978-7-117-12991-6/R.2992，人民卫生出版社。