青年研究员，博士生导师
Email:shangyu_hong@fudan.edu.cn
工作经历
2001年本科毕业于武汉大学生科院，2007年博士毕业于中科院上海生科院生化细胞所，毕业后于哈佛大学医学院进行博士后研究和工作，2017年受聘复旦大学生科院任青年研究员。主持多项国家级科研项目。
研究方向
1. 研究饮食与营养代谢相关基因的交互作用；
2. 研究肝脏和脂肪组织糖脂代谢稳态与代谢性疾病发病机制。
招生专业
生物化学与分子生物学、生理学、生物与医药
获奖情况
获2018年上海市“浦江人才”，2020年湖北省科技进步三等奖（本人排名第四）。
代表论文
1. Zhuang Wei, Jigang Lei, Feng Shen, Yuxiang Dai, Yan Sun, Yilian Liu, Yan Dai, Shilong Wang, Zhengjun Chen#, Kan Liao# and Shangyu Hong#. Cavin1 deficiency causes disorder of hepatic glycogen metabolism and neonatal death by impacting fenestrations in liver sinusoidal endothelial cells. Adv. Sci. 2020 Aug 21;7(19):2000963.
2. Shanshan Guo, Yiru Huang, Yan Zhang, He Huang, Shangyu Hong# and Tiemin Liu#. Impacts of exercise interventions on different diseases and organ functions in mice. J. Sport Health Sci. 2020 Jan; 9(1): 53-73.
3. Shangyu Hong#, Bo Zhai, Pavlos Pissios#. Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism. Biochemistry. 2018 Oct 9;57(40):5775-5779.
4. Shangyu Hong, Wei Song, Peter-James H. Zushin, Bingyang Liu, Mark P. Jedrychowski, Amir I. Mina, Zhaoming Deng , Dimitrije Cabarkapa, Jessica A. Hall , Colin J. Palmer, Hassan Aliakbarian, John Szpyt, Steven P. Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S. Banks. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab. 2018 Jun;12:25-38.
5. Shangyu Hong, Jose M Moreno-Navarrete, Xiaojing Wei, Yusuke Kikukawa, Iphigenia Tzameli, Deepthi Prasad, Yoonjin Lee, John M Asara, Jose Manuel Fernandez- Real, Eleftheria Maratos-Flier and Pavlos Pissios. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94.
6. Alexander M. Real*, Shangyu Hong* and Pavlos Pissios. Nicotinamide N-Oxidation by CYP2E1 in Human Liver Microsomes. Drug Metab Dispos. 2013 41 (3), 550-553
7. Shangyu Hong, Hairong Huo, Jinfei Xu and Kan Liao. Insulin-Like Growth Factor-1 Receptor Signaling in 3T3-L1 Adipocyte Differentiation Requires Lipid Rafts But Not Caveolae. Cell Death Differ. 2004 Jul;11(7):714-23.
