工作经历
2021.12-至今，复旦大学人类表型组研究院，青年研究员
2021.1-2021.6，美国Wistar研究所，研究助理
2017.4-2020.12，美国Wistar研究所，博士后
2015.8-2017.4，美国宾夕法尼亚大学大学医学院，博士后
2007-2014，中国科学院上海生命科学学院生物化学与细胞生物学研究所，博士
研究方向
细胞衰老与相关疾病发生的分子机制
靶向衰老促进健康老龄化
获奖情况
2023年度复旦大学“卓学”计划
荣获2022年度中国生物物理学会-女科学家论坛科研成果优秀奖
上海市领军人才（2021海外）计划支持
招生专业
生物与医药
代表论文
1. Li Yang, Jianwei You, Xincheng Yang, Ruishu Jiao, Jie Xu, Yue zhang, Wen Mi, Lingzhi Zhu, Youqiong Ye, Ruobing Ren, Delin Min, Meilin Tang, Li Chen, Fuming Li & Pingyu Liu#. ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation. 2025. Nature Communications, 16:2071.
2. Fuming Li *#, Pingyu Liu*, Wen Mi, Liucheng Li, Nicole M Anderson, Nicholas P Lesner, Michelle Burrows, Jacqueline Plesset, Ariana Majer, Guanlin Wang, Jinyang Li, Lingzhi Zhu, Brian Keith, M Celeste Simon#. Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer. 2024. Nature Cancer, 5(1):131-146.
3. Xue Hao, Yusuke Shiromoto, Masayuki Sakurai, Aaron Havas, Lu Wang, Shelley L Berger, Peter D Adams, Kazuko Nishikura, Andrew Kossenkov, Pingyu Liu# and Rugang Zhang#. ADAR1 downregulation by autophagy drives senescence independently of RNA editing by enhancing p16INK4a levels. 2022. Nature Cell Biology, 24(8):1202-1210.
4. Pingyu Liu, Fuming Li, Jianhuang Lin, Takeshi Fukumoto, Timothy Nacarelli, Xue Hao, Andrew V. Kossenkov, M. Celeste Simon and Rugang Zhang. m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype. 2021. Nature Cell Biology (23), 355-365.
5. Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher and Rugang Zhang. Topoisomerase 1 cleavage complex enables pattern recognition and in!ammation during senescence. 2020. Nature Communications 11: 908.
6. Timothy Nacarelli, Pingyu Liu and Rugang Zhang. Epigenetic Basis of Cellular Senescence and Its Implications in Aging. 2017. Genes (8), 343.
7. Pingyu Liu, Xiaoyang Dou, Chang Liu, Lingbo Wang, Can Xing, Guangdun Peng, Jun Chen, Fang Yu, Yunbo Qiao, Lu Song, Yuxuan Wu, Chunmei Yue, Jinsong Li, Jing-Dong J. Han, Ke Tang and Naihe Jing. Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate. 2015. Nature Communications 6:6830.
8. Pingyu Liu, Xiaoyang Dou, Guangdun Peng, Jing-Dong Jackie Han and Naihe Jing. Genome-wide analysis of histone acetylation dynamics during mouse embryonic stem cell neural differentiation. 2015. Genomics Data (5), 15–16.
