工作经历
国家杰出青年科学基金获得者、英国皇家化学会会士、国家重点研发计划项目首席。1986年获西北轻工业学院(现陕西科技大学)学士、1994年获伦敦大学博士学位。1992-2005年先后在英国BBSRC食品研究所、帝国理工学院生物医学部任Senior Scientist等职。2005-2014年先后任中科院武汉物数所研究员、博导、研究部副主任、中科院生物磁共振分析重点实验室创建主任。2014年加盟复旦大学生命科学学院。
曾任英国NHS、科技部973及蛋白质重大计划等评审专家、J Proteome Res编委。发表Nature、Nat Microbiol、Nat Aging、Cell Rep、Cell Rep Med、Immunity、PNAS、EMBO J、J Hepatol、JACS及Anal Chem等SCI论文220余篇,被引1.5万余次(H指数~70);有国内外发明专利10余项。部分工作被Science、Nature等作为“研究亮点”专文评述。
现任中国生物物理学会代谢组学分会会长;中国抗癌协会肿瘤代谢分会、中国生物化学与分子生物学会脂质与脂蛋白委员会、中国营养学会基础营养分会、中国生物物理学会自由基生物学及医学分会等常务理事,国际实验磁共振大会(ENC)执委(大中华地区唯一);Metabolomics、Arch Pharm和《基础医学与临床》等编委,Nutrition & Metabolism及Phenomics等副主编。
Personal website: http://www.metabolome.cn/
研究方向
定量代谢组学技术及引用,包括定量代谢组学与脂质组学新技术体系、重要疾病发生发展和有效干预的代谢组机制、宿主代谢与肠道菌群相互作用机制与健康。本人研究代谢物功能及代谢组学30余年,发展了高通量超灵敏代谢组学、代谢组与转录组/蛋白质组/微生物组数据整合分析等系列技术,并用以研究疾病发生发展的分子机制。曾主持国家杰出青年科学基金、精准医学国家重点研发计划、国家自然科学基金重大、973等项目课题多项。现承担“生物前沿技术”国家重点研发计划、国家创新群体、上海市级重大专项等项目。
获奖情况
英国皇家化学会会士(2005)
国家杰出青年科学基金(2008)
国务院政府特殊津贴、新世纪百千万人才工程国家级人选称号(2009)
王天眷波谱学奖(2010)
武汉市优秀科技工作者(2011)
“精准医学研究”国家重点研发计划项目首席(2017-2020)
“生物前沿技术”国家重点研发计划项目首席(2022-2027)
招生专业
生物化学及分子生物学 代谢组学 人类表型组学 生命分析化学 分析化学
代表论文
1、Q. Huang, et al, “A metabolome-derived score predicts metabolic dysfunction-associated steatohepatitis and mortality from liver disease”, J Hepatol, 82:781-793, 2025
2、H. Wang, et al, “Simultaneous profiling of multiple phosphorylated metabolites in typical biological matrices via ion-pair reversed-phase ultrahigh-performance liquid chromatography and mass spectrometry”, Anal Chem, 97:1681–1687, 2025.
3、Y. Sun, et al, “Simultaneous quantification of carboxylate enantiomers in multiple human matrices with the hydrazide-assisted ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry”, Anal Chem, 96:18141-18149 2024.
4、J. Xiao, et al, “25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages”, Immunity, 57:1087–1104, 2024
5、Z.L. Wang, et al, “Total synthesis of all stereoisomers of C5-glyceryl-methyl-20-deoxycytidine 5gmC and their occurrence in Chlamydomonas reinhardtii”, Cell Rep Phys Sci, 5:102041, 2024
6、Y.N. Pu, et al, “Gut microbial features and circulating metabolomic signatures of frailty in older adults”, Nat Aging, 4:1249-1262, 2004
7、Q.S. Chen, et al, “A novel endogenous retention-index for minimizing retention-time variations in metabolomic analysis with reversed-phase ultrahigh-performance liquid-chromatography and mass spectrometry”, Talanta, 268:125318, 2024.
8、J.X. Zhang, et al, “Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry”, J Pharm Anal, 14:140-148, 2024.
9、C.C. Zhang, et al, “Detecting sub-micromolar analytes in mixtures with a 5-min acquisition on 600 MHz NMR spectrometers”, J Am Chem Soc, 145:25513–25517, 2023
10、Y.B. Feng, et al, “Anopheline mosquitoes are protected against parasite infection by tryptophan catabolism in gut microbiota”, Nat Microbiol, 7:707-715, 2022.
11、Z.M. Hou, et al, “Inhibiting 3bHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer”, Cell Rep Med, 3:100561, 2022.
12、J.H. Liu, et al, “Simultaneous quantification of 70 elements in biofluids within 5 min using inductively coupled plasma mass spectrometry to reveal elementomic phenotypes of healthy Chinese adults”, Talanta, 238:123720, 2022
13、M. F. Xia, et al, “Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR_based lipoprotein profiling”, J Hepatol, 74:974-977, 2021.
14、Y. Xu, et al, “Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues”, EMBO J. e108069, 2021.\
15、M.F. Wang, et al, “Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH”, Cell Rep, 35:108992, 2021
16、J.H. Xue, et al, “A vitamin-C-derived DNA modification catalysed by an algal TET homologue”, Nature, 569:581–585, 2019.
17、H. Lin, et al, “Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model”, J Agric Food Chem, 67:3624-3632. 2019.【高被引, 年均被引>30次】
18、Q.F. Wan, et al, "Quantitative 13C traces of glucose fate in hepatitis B virus infected hepatocytes", Anal Chem, 89:3293–3299, 2017
19、L. Sun, et al, "cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions". Cell Res, 25:429–444, 2015.
20、M. Li, et al, “Human symbiotic gut microbes specifically modulate metabolic phenotypes”, PNAS, 105:2117-2122, 2008. 【高被引, 年均被引>50次】
论文及引用Publication List
publons.com/researcher/2776607/huiru-tang/
www.researchgate.net/profile/Huiru-Tang/research