工作经历
研究方向肿瘤免疫和空间组学。曾任英国爱丁堡大学癌症研究中心和生殖健康中心双聘终身教授。长期专注于肿瘤转移和免疫微环境的研究，阐明了巨噬细胞在癌症转移中的重要作用，并开创了转移相关巨噬细胞的研究领域。目前已在Nature、Cell、Nature Review Immunology等知名国际期刊发表了近40篇高水平学术论文，总引用超14300次，累计影响因子334，其中8篇被web of science评为高被引文章，已转化国际发明一项，主持国际重大科研项目折合人民币超2800余万元。
课题组在原有工作基础上，负责搭建了具有国际先进领先水平的复旦大学空间多组学测-算-控整合研究平台，将采用标准化研究，数据驱动，AI整合算法，功能验证四位一体的研究方式促进跨学科交叉融合，推动各相关研究领域的共同进步。
研究方向
空间组学；肿瘤免疫；肿瘤微环境；生物信息学
获奖情况
2015年 爱丁堡大学学院早期成就奖
2014年 英国癌症研究职业发展奖
2013年 Movember-Prostate Cancer Foundation 挑战奖
2013年 Dennis Shields纪念基金研究奖： 最佳博士后研究奖
2012年 Susan G. Komen for the Cure 博士后奖
2012年 美国癌症研究协会在训学者奖（103期）
2011年 美国癌症研究协会在训学者奖（102期）
招生专业
生物学
代表论文
1. Yang Y, Chen Y, Pei P, Fan Y, Wang S, Zhang H, Zhao D, Qian BZ, Zhang F. Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging. Nat Nanotechnol. 2023 Jun 22. doi: 10.1038/s41565-023-01422-2.
3. Li XF, Selli C, Zhou H, Cao J, Wu S, Ma RY, Lu Y, Zhang CB, Xun B, Lam AD, Pang XC, Fernando A, Zhang Z, Unciti-Broceta A, Carragher NO, Ramachandran P, Henderson NC, Sun LL, Hu HY, Li GB, Sawyers C, Qian BZ. Macrophages promote anti-androgen resistance of prostate cancer bone disease. J Exp Med. 2023 Apr 3;220(4):e20221007. doi: 10.1084/jem.20221007.
4. Ma RY; Black A; Qian BZ. Macrophage diversity in cancer revisited in the era of single-cell omics. Trends Immunol. 2022 Jul;43(7):546-563. DOI: 10.1016/j.it.2022.04.008
5. Zhou Y, Yang D, Yang QC, Lv XB, Huang WT, Zhou Z, Wang YL, Ding X, Tang LN, Zhang JJ, Yin JY, Huang YJ, Yu WX, Wang YG, Chen- Zhou L, Su Y, Guo-Wei Qian, He AN, Sun YJ, Shen Z, Qian BZ, Chen PZ, Yao Y, Hu HY. Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma. Nat Com. 2020 Dec 10;11(1):6322.
6. Ma RY, Zhang H, Li XF, Zhang CB, Selli C, Tagliavini G, Prost S, Sims AH, Hu HY, Ying T, Wang Z, Ye Z, Pollard JW, Qian BZ. Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth. J Exp Med. 2020, 217 (11): e20191820
7. Pang, X, Gong, K, Zhang, X, Wu, S, Cui, Y, and Qian BZ (2019). Osteopontin as a multifaceted driver of bone metastasis and drug resistance. Pharmacol. Res. 144, 235-244.
8. Graham N, Qian BZ. Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis. Int. J. Mol. Sci. 2018, 19(4), 1121; doi:10.3390/ijms19041121
9. Gómez-Cuadrado L, Tracey N, Ma R, Qian BZ, Brunton VG Mouse models of metastasis: progress and prospects. Disease Models and Mechanisms. 2017 Sep 1;10(9):1061-1074. doi: 10.1242/dmm.030403.
10. Qian BZ. Inflammation fires up cancer metastasis. Seminars in Cancer Biology. 2017 Aug 31. pii: S1044-579X(17)30210-9. doi: 10.1016/j.semcancer.2017.08.006
11. Cao J, Liu J, Xu R, Zhu X, Zhao X, Qian BZ. Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: A systematic review and meta-analysis. Oncotarget. 2017 Jun 27; : 1–9. doi: 10.18632/oncotarget.18743.
12. Qin W, Zheng Y, Qian BZ#, Zhao M# Prostate cancer stem cells and nanotechnology: a focus on Wnt signaling. Front. Pharmacol. 2017 Mar 28; 8: 153 (# co-corresponding author)
13. Hughes R*, Qian BZ* Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW and Lewis CE. Perivascular M2 macrophages Stimulate Tumor Relapse After Chemotherapy. Cancer Research. 2015 Sep 1;75(17):3479-91 (co-first author)
14. Qian BZ#, Zhang H, Li J, He AT, Yeo EJ, Soong DYH, Carragher N, Munro A, Chang A, Bresnick AR, Lang RA and Pollard JW# FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J Exp Med 2015 Aug 24; 212(9):1433-48. (# co-corresponding author)
15. Harney AS, Arwert EN, Entenberg D, Wang Y, Qian BZ, Pollard JW, Jones JG and Condeelis JS. Real-time imaging reveals local, transient vascular permeability and tumor cell intravasation by Tie2Hi macrophage-derived VEGFA. Cancer Discov 2015 Sep;5(9):932-43.
16. Kitamura T, Qian BZ, Soogn D, Cassetta L, Noy R, Sugano G, Kato Y, Li J and Pollard JW CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J Exp Med 2015 Jun 29;212(7):1043-59.
17. Kitamura T, Qian BZ and Pollard JW Immune cell promotion of metastasis. Nature Review Immunology 2015 Feb. 2: 73-86.
18. Qian BZ, Li J, Zhang H, Kitamura T, Campion LR, Kaiser EA, Zhang J, Snyder LA and Pollard JW. CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis. Nature. 475, 222-25 July 14, 2011.
19. Qian BZ, Pollard JW. Macrophage Diversity Enhances Tumor Progression and Metastasis. Cell. 141, 39-51 April 2, 2010
20. Qian BZ, Deng Y, Im JH, Muschel RJ, Zou Y, et al. 2009. A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth. PLoS ONE. 4(8): e6562.
