工作经历
浙江大学 临床医学学士学位（1993）
浙江大学 神经病学硕士学位（1996）
复旦大学 神经病学博士学位（2001）
美国密歇根大学医学院 神经外科博士后（2001-2002）
美国芝加哥大学医学院 神经内科与Jack Miller周围神经病中心博士后（2002-2007）
复旦大学附属华山医院神经科/复旦大学神经病学研究所（2007-至今）
研究方向
（1）运动神经元病/肌萎缩侧索硬化（“渐冻症”）动物模型与发病机制研究；着重在神经轴浆逆行性运输障碍和神经元死亡机制的研究；
（2）基于队列的神经系统免疫病的临床表型与机制研究；着重于各种脑炎、视神经脊髓炎谱系疾病、多发性硬化、格林巴利综合征、重症肌无力等疾病的深度免疫表型研究；
（3）应用分子生物学、免疫荧光标记、生物信息学等技术进行神经系统免疫疾病高通量精准检测新技术和生物标记物的转化研究。
招生专业
神经生物学或免疫学（或生物信息学）
代表论文
1、Bo Deng, Jingguo Wang, Hai Yu, Lei Jin, Yue Qiu, Xiaoni Liu, Pengyu Wang, Xiang Zhang, Xiangjun Chen*. Area Postrema Syndrome in Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy A Case Series and Literature Review. Neurology: Neuroimmunology & Neuroinflammation. 2022;9:e200029. doi:10.1212/NXI.0000000000200029
2、Bo Deng#, Mengfei Cai#, Yue Qiu, Xiaoni Liu, Hai Yu, Xiang Zhang, Huifen Huang, Xiuhe Zhao, Wenbo Yang, Siqi Dong, Lei Jin, Shuguang Chu, and Xiangjun Chen*. MRI Characteristics of Autoimmune Encephalitis With Autoantibodies to GABAA Receptor: A Case Series. Neurology: Neuroimmunology & Neuroinflammation. 2022;9:e1158. doi:10.1212/NXI.0000000000001158
3、Jia-Tong Li, Si-Qi Dong, Dong-Qing Zhu, Wen-Bo Yang, Ting Qian, Xiao-Ni Liu and Xiang-Jun Chen*. Expanding the Phenotypic and Genetic Spectrum of Neuromuscular Diseases Caused by DYNC1H1 Mutations. Frontiers in Neurology. July 2022 | Volume 13 | Article 943324 https://doi.org/10.3389/fneur.2022.943324
4、Siqi Dong#, Dongqing Zhu#, Wenbo Yang, Jiatong Li, Xiangjun Chen*. Prominent lower motor neuron involvement in patients with intermediate‑length CAG repeats in ATXN3 gene. Neurological Sciences. Received: 3 June 2022/Accepted: 5 August 2022. https://doi.org/10.1007/s10072-022-06325-z
5、Xiang Zhang, Xiaoni Liu, Hai Yu, Bo Deng, Yue Zhang, Xiangjun Chen*, Longitudinal evaluation of clinical characteristics of Chinese neuromyelitis optica spectrum disorder patients with different AQP4-IgG serostatus. Multiple Sclerosis and Related Disorders. 62(2022)103786.
6、Gao WQ#, Li YY#, Liu XH, Wang S, Mei PC, Chen ZJ, Liu KW, Li SH, Xu XW, Gan JH, Wu JX, Ji CN, Ding C, Liu X, Lai YP, He HS, Lieberman J, Wu H, Chen XJ*, and Li JX*. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death & Differentiation，2021; https://doi.org/10.1038/s41418-021-00867-z.
7、Dong SQ#, Liu XN#, Yang WB, Zhou YN, Wang JC, Chen XJ*. An exon 5 mutation (c.425G>C, p.Gly141Ala) in the SOD1 gene in a Chinese family associated with incomplete penetrance. Amyotroph Lateral Scler Frontotemporal Degener. 2020:1-4. DOI: 10.1080/21678421.2020.1738496
8、Chen XJ, Levedakou EN, Millen KJ, Wollmann RL, Soliven B, Popko B. Proprioceptive Sensory Neuropathy in Mice with a Mutation in the Cytoplasmic Dynein Heavy Chain 1 Gene. Journal of Neuroscience, 2007, 27(52): 14515-14524
