高强教授,兼职高级专家

教授,主任医师,博士生导师,长江学者

Email:gaoqiang@fudan.edu.cn

   工作经历

复旦大学附属中山医院肝外科主任医师、教授、博士生导师。复旦大学表型组研究院PI;复旦大学肝癌研究所办公室主任。“长江学者奖励计划”特聘教授、国家“万人计划”、国家优秀青年科学基金、卫生系统“全国青年岗位能手”、上海市优秀学科带头人和优秀学术带头人获得者。

  获奖情况

复旦大学“校长奖”(2008)

复旦大学“十大医务青年” (2011)

上海市“银蛇奖”二等奖(2013)

树兰医学青年奖(2015)

教育部青年科学奖(2017)

上海市青年科技英才(2020)

国家科技进步二等奖(2020)

  研究方向

肿瘤的异质性和个体化治疗。以肝胆肿瘤为对象,综合利用临床样本、患者来源的肿瘤模型、动物模型、大数据分析和多组学技术等先进手段,深入研究肿瘤个体化精准诊疗的新靶标、新策略和新机制。


  招生专业


肿瘤学(肿瘤免疫学、肿瘤精准诊疗)

  代表论文

1. Wu Y, Yang S, Ma J, Chen Z, Song G, Rao D, Cheng Y, Huang S, Liu Y, Jiang S, Liu J, Huang X, Wang X, Qiu S, Xu J, Xi R, Bai F, Zhou J, Fan J, Zhang X*,Gao Q*. Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level. Cancer Discov. 2022 Jan; 12(1):134-53.

2. Dong L, Lu D, Chen R, Lin Y, Zhu H, Zhang Z, Cai S, Cui P, Song G, Rao D, Yi X, Wu Y, Song N, Liu F, Zou Y, Zhang S, Zhang X, Wang X, Qiu S, Zhou J, Wang S, Zhang X, Shi Y, Figeys D, Ding L, Wang P, Zhang B, Rodriguez H, Gao Q*, Gao D*, Zhou H*, Fan J*.  Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma. Cancer Cell. 2022 Jan; 40(1):70-87 e15.

3. Ding GY, Ma JQ, Yun JP, Chen X, Ling Y, Zhang S, Shi JY, Chang YQ, Ji Y, Wang XY, Tan WM, Yuan KF, Yan B, Zhang XM, Liang F, Zhou J, Fan J, Zeng Y*, Cai MY*, Gao Q*. Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinoma. J Hepatol. 2022 Mar; 76(3):608-18.

4. Song G, Shi Y, Meng L, Ma J, Huang S, Zhang J, Wu Y, Li J, Lin Y, Yang S, Rao D, Cheng Y, Lin J, Ji S, Liu Y, Jiang S, Wang X, Zhang S, Ke A, Wang X, Cao Y, Ji Y, Zhou J, Fan J*, Zhang X*, Xi R*, Gao Q*. Single-cell transcriptomic analysis suggests two molecularly subtypes of intrahepatic cholangiocarcinoma. Nat Commun. 2022 Mar; 13(1):1642.

5. Shi JY, Wang X, Ding GY, Dong Z, Han J, Guan Z, Ma LJ, Zheng Y, Zhang L, Yu GZ, Wang XY, Ding ZB, Ke AW, Yang H, Wang L, Ai L, Cao Y, Zhou J, Fan J, Liu X*, Gao Q*. Exploring prognostic indicators in the pathological images of hepatocellular carcinoma based on deep learning. Gut. 2021 May; 70(5):951-61.

6. Dong LQ, Peng LH, Ma LJ, Liu DB, Zhang S, Luo SZ, Rao JH, Zhu HW, Yang SX, Xi SJ, Chen M, Xie FF, Li FQ, Li WH, Ye C, Lin LY, Wang YJ, Wang XY, Gao DM, Zhou H, Yang HM, Wang J, Zhu SD, Wang XD, Cao Y, Zhou J, Fan J, Wu K*,Gao Q*. Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma. J Hepatol. 2020 May; 72(5):896-908.

7. Gao Q, Zhu H, Dong L, Shi W, Chen R, Song Z, Huang C, Li J, Dong X, Zhou Y, Liu Q, Ma L, Wang X, Zhou J, Liu Y, Boja E, Robles AI, Ma W, Wang P, Li Y, Ding L, Wen B, Zhang B, Rodriguez H, Gao D*, Zhou H*, Fan J*. Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma. Cell. 2019 Oct; 179(2):561-577.e22.

8. Duan M, Hao J, Cui S, Worthley DL, Zhang S, Wang Z, Shi J, Liu L, Wang X, Ke A, Cao Y, Xi R, Zhang X, Zhou J, Fan J*, Li C*, Gao Q*.Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing. Cell Res. 2018 Mar; 28(3):359-373.

9. Dong LQ, Shi Y, Ma LJ, Yang LX, Wang XY, Zhang S, Wang ZC, Duan M, Zhang Z, Liu LZ, Zheng BH, Ding ZB, Ke AW, Gao DM, Yuan K, Zhou J, Fan J*, Xi R, * Gao Q*. Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma. J Hepatol. 2018 Jul; 69(1):89-98.

10.Gao Q, Wang ZC, Duan M, Lin YH, Zhou XY, Wang XY, Niu G, Xia Y, Deng M, Liu LZ, Shi JY, Yang LX, Zhang S, Ding ZB, Zhou J, Liang CM, Cao Y, Xiong L, Xi R, Shi YY*, Fan J*. Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents. Gastroenterology. 2017 Jan; 152(1):232-242.e4.